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SML0868

Sigma-Aldrich

Purmorphamine

≥98% (HPLC), powder, Hedgehog signaling activator

Synonym(e):

2-(1-Naphthoxy)-6-(4-morpholinoanilino)-9-cyclohexylpurine; 9-Cyclohexyl-N-[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-

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CHF 164.00
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CHF 571.00

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5 MG
CHF 164.00
25 MG
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About This Item

Empirische Formel (Hill-System):
C31H32N6O2
CAS-Nummer:
483367-10-8
Molekulargewicht:
520.62
UNSPSC-Code:
51111800
NACRES:
NA.77

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Produktbezeichnung

Purmorphamine, ≥98% (HPLC)

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Farbe

white to beige

Löslichkeit

DMSO: 5 mg/mL, clear (warmed)

Lagertemp.

−20°C

SMILES String

N7(CCOCC7)c1ccc(cc1)Nc2nc(nc5[n](cnc52)C6CCCCC6)Oc3c4c(ccc3)cccc4

InChI

1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)

InChIKey

FYBHCRQFSFYWPY-UHFFFAOYSA-N

Anwendung

Purmorphamine has been used to study the consequences of upregulation of Hedgehog signalling pathway in Tupfel long fin strain Zebrafish.[1]

Biochem./physiol. Wirkung

Purmorphamine activates the Hedgehog (Hh) signaling pathway, directly binding to the Smoothened (Smo) receptor.
Purmorphamine activates the Hedgehog (Hh) signaling pathway, directly binding to the Smoothened (Smo) receptor. In various studies, purmorphamine has been shown to induce osteoblast differentiation, generate cardiomyocytes from human embryonic stem cells, increase the neuronal differentiation of a human striatal neural stem cell line, and to differentiate human umbilical cord mesenchymal stem cells (hUCMSCs) into motoneurons.

Piktogramme

Health hazard
GHS08

Signalwort

Warning

H-Sätze

H341

Gefahreneinstufungen

Muta. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000418840
0000418840
0000366523
0000366522
0000356999

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Shabana Amanda Ali et al.
Arthritis & rheumatology (Hoboken, N.J.), 68(1), 127-137 (2015-09-01)
With no effective therapies to attenuate cartilage degeneration in osteoarthritis (OA), the result is pain and disability. Activation of hedgehog (HH) signaling causes changes related to the progression of OA, with higher levels of Gli-mediated transcriptional activation associated with increased
Sara Brilha et al.
Scientific reports, 7(1), 16031-16031 (2017-11-24)
Central nervous system tuberculosis (CNS TB) has a high mortality and morbidity associated with severe inflammation. The blood-brain barrier (BBB) protects the brain from inflammation but the mechanisms causing BBB damage in CNS TB are uncharacterized. We demonstrate that Mycobacterium
Methylation microarray studies highlight PDGFA expression as a factor in biliary atresia.
Cofer Z C, et al.
PLoS ONE, 11(3), e0151521-e0151521 (2016)
Roberto Simone et al.
EMBO molecular medicine, 10(1), 22-31 (2017-11-09)
Intronic GGGGCC repeat expansions in
Anna Drannik et al.
PloS one, 12(2), e0171668-e0171668 (2017-02-09)
Sonic hedgehog (Shh) is a morphogen essential to the developing nervous system that continues to play an important role in adult life by contributing to cell proliferation and differentiation, maintaining blood-brain barrier integrity, and being cytoprotective against oxidative and excitotoxic
Alle zugehörigen Dokumente anzeigen

Questions

  1. What is the stability of purmorphamine as solid and in solution of DMSO ?

    1 answer

    1. This product is not assigned an expiration date or retest schedule. Products that are robust and extremely stable in their original unopened container are not assigned an expiration date or retest schedule. These products will not have dating reported on either the label or the Certificate of Analysis. Products without an expiration or retest date are covered by a warranty period of 1 year from the date of product shipment. Full product dating information can be reviewed at the following link: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/190/408/product-dating-information-ms.pdf. Stability in solution has not been internally validated. Other sources recommend storing at -20°C and using it within 1 year. It is advised to aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

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