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SML0289

Sigma-Aldrich

Bromfenac sodium

≥98% (HPLC)

Synonym(e):

2-Amino-3-(4-bromobenzoyl)benzeneacetic acid sodium salt

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10 MG
CHF 73.20
50 MG
CHF 300.00

About This Item

Empirische Formel (Hill-System):
C15H11BrNNaO3
CAS-Nummer:
91714-93-1
Molekulargewicht:
356.15
MDL-Nummer:
MFCD03701673
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825297
NACRES:
NA.77

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Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

faintly yellow to dark yellow

Löslichkeit

H2O: ≥5 mg/mL

Lagertemp.

2-8°C

SMILES String

[Na+].Nc1c(CC([O-])=O)cccc1C(=O)c2ccc(Br)cc2

InChI

1S/C15H12BrNO3.Na/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19;/h1-7H,8,17H2,(H,18,19);/q;+1/p-1

InChIKey

HZFGMQJYAFHESD-UHFFFAOYSA-M

Angaben zum Gen

human ... PTGS1(5742) , PTGS2(5743)

Anwendung

Bromfenac sodium has been used:
  • to study its ability to bind to melanin[1]
  • in the synthesis of bromfenac indolinone standard[2]
  • to analyze its permeability in porcine conjunctiva[3]

Biochem./physiol. Wirkung

Bromfenac exhibits antipyretic and prostaglandin synthetase inhibiting properties.[4] It has therapeutic properties against the reduction of ocular pain and inflammation in postoperative cataract patients.[5] Bromfenac acts as an effective agent against allergic conjunctivitis.[4] It has the potential to treat acute muscle pain, osteoarthritis, and rheumatoid arthritis.[2]
Bromfenac is a nonsteroidal anti inflammatory drug (NSAID) that inhibits both COX1 and COX2. It is used as an opthalmic analgesic.
Bromfenac is a nonsteroidal anti inflammatory drug (NSAID); COX1 and COX2 inhibitor; opthalmic analgesic.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000365928
0000303379
0000365928
0000375431
0000227632

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Dexamethason powder, BioReagent, suitable for cell culture, ≥97%

Sigma-Aldrich

D4902

Dexamethason

Neal A Sher et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 25(2), 214-220 (2009-02-27)
To compare the efficacy of two topical nonsteroidal anti-inflammatory drugs with regards to the control of pain, burning, photophobia, foreign body sensation, and epithelial healing rates in patients who underwent photorefractive keratectomy (PRK). Two hundred twelve eyes were randomized to
Ester Carreño et al.
Clinical ophthalmology (Auckland, N.Z.), 6, 637-644 (2012-05-10)
Ophthalmic bromfenac sodium sesquihydrate is a topically applied selective cyclooxygenase (COX)-2 inhibitor. It is similar to amfenac, except for a bromine atom at the C(4) of the benzoyl ring position, which markedly affects its in vitro and in vivo potency
Keith A Warren et al.
Retina (Philadelphia, Pa.), 30(2), 260-266 (2010-02-23)
The purpose of this study was to evaluate the addition of topical nonsteroidal antiinflammatory drugs (NSAIDs) to intravitreal corticosteroid and antivascular endothelial growth factor injections for the treatment of chronic cystoid macular edema. Thirty-nine patients with chronic pseudophakic cystoid macular
Christina Flaxel et al.
Retina (Philadelphia, Pa.), 32(3), 417-423 (2011-08-25)
To evaluate whether bromfenac eyedrops and ranibizumab intravitreal injections would provide added efficacy over ranibizumab alone. This was a single-site, multiinvestigator, prospective, open-label, interventional, Phase II study of patients with new or recurrent exudative/neovascular age-related macular degeneration. Thirty eyes were
Jeffrey S Heier et al.
Retina (Philadelphia, Pa.), 29(9), 1310-1313 (2009-11-26)
To assess vitreous concentrations of nonsteroidal antiinflammatory drugs (NSAIDs) and prostaglandin E(2) in patients treated with NSAIDs before vitrectomy. This was an investigator-masked, randomized, multicenter study. Patients received ketorolac 0.4% 4 times a day, bromfenac 0.09% 2 times a day
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