P9623

Paroxetin -hydrochlorid Hemihydrat

≥98% (HPLC), powder, serotonin reuptake inhibitor

• Synonym(e): (3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)-methyl]-4-(4-fluor-phenyl)-piperidin -hydrochlorid Hemihydrat
• Empirische Formel (Hill-System): C₁₉H₂₀FNO₃ · HCl · .5 H₂O
• CAS-Nummer: 110429-35-1
• Molekulargewicht: 374.83
• MDL-Nummer: MFCD03658863
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278249
• NACRES: NA.77

Eigenschaften

• Produktbezeichnung: Paroxetin -hydrochlorid Hemihydrat, ≥98% (HPLC), powder
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white
• Ersteller: GlaxoSmithKline
• SMILES String: O.Cl[H].Fc1ccc(cc1)[C@@H]2CCNC[C@H]2COc3ccc4OCOc4c3
• InChI: 1S/C19H20FNO3.ClH.H2O/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18;;/h1-6,9,14,17,21H,7-8,10-12H2;1H;1H2/t14-,17-;;/m0../s1
• InChIKey: QRQSGFFISBKLMZ-YHOFXEKLSA-N
• Angaben zum Gen: human ... SLC6A4(6532)

Beschreibung

Anwendung

Paroxetine hydrochloride hemihydrate has been used: as an antidepressant to study its effects on neural stem cells (NSCs) from embryonic rat hippocampus in vitro[1]; as a CYP 2D6 inhibitor to study its effects on the in vitro production by human recombinant CYP 2D6 of the phenolic metabolites[2]; as an antidepressant to study its effects on the expression of pituitary adenylate cyclase activating polypeptide (PACAP), its receptors and brain-derived neurotrophic factor (BDNF) in rat primary hippocampal neurons[3]

Biochem./physiol. Wirkung

Ein selektiver Serotonin-Wiederaufnahmehemmer, Antidepressivum

Paroxetin-hydrochlorid Hemihydrat ist einer der wirksamsten und selektivsten der selektiven Serotonin-Wiederaufnahmehemmer (SSRI), Antidepressivum

Paroxetine is a phenylpiperidine derivative.[4] It has the ability to cross placenta. Paroxetine is known to increase the risk of congenital cardiac malformations.[5] It might be useful in hormone replacement therapy for treating vasomotor symptoms during menopause.[6] It is known to ameliorate the effects of panic disorder, obsessive‐compulsive disorder and social phobia.[4]

Leistungsmerkmale und Vorteile

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Rechtliche Hinweise

Sold with the permission of GlaxoSmithKline

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H302,H317,H319,H335,H410
• P-Sätze: P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves