S6319

Sertralin -hydrochlorid

≥98% (HPLC), Selective serotonin reuptake inhibitor (SSRI), powder

• Synonym(e): (1S,4S)-4-(3,4-Dichlor-phenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalinamin -hydrochlorid
• Empirische Formel (Hill-System): C₁₇H₁₇NCl₂ · HCl
• CAS-Nummer: 79559-97-0
• Molekulargewicht: 342.69
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278601
• NACRES: NA.77
• MDL number: MFCD00895772
• Assay: ≥98% (HPLC)
• Form: powder
• Storage condition: desiccated

Eigenschaften

• Produktname: Sertralin -hydrochlorid, ≥98% (HPLC)
• assay: ≥98% (HPLC)
• form: powder
• optical activity: [α]/D +33 to +43°, c = 2.0 in methanol
• storage condition: desiccated
• color: white
• solubility: DMSO: >20 mg/mL
• SMILES string: ClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl
• InChI: 1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1
• InChI key: BLFQGGGGFNSJKA-XHXSRVRCSA-N
• Gene Information: human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363), SLC6A4(6532)

Beschreibung

Application

The effect of exposure of sertraline hydrochloride was studied in chronically prepared ovine fetus. It was used in glucocorticoid function assay to study the effect of antidepressants on glucocorticoid receptor function in humans.

Biochem/physiol Actions

Ein selektiver Serotonin-Wiederaufnahmehemmer, Antidepressivum

Sertraline suppresses platelet function and exhibits antiplatelet and endothelium protective functions. It relieves depression and improves the quality of life in patients with cardiovascular disorders. It can also be prescribed to treat depression in Parkinson′s disease.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• pictograms: GHS08,GHS07,GHS09
• signalword: Warning
• hcodes: H302,H373,H410
• pcodes: P260 - P264 - P270 - P273 - P301 + P312 - P314
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2
• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)