M1508

4-Methylumbelliferone sodium salt

fluorogenic, ≥98% (HPLC), crystalline

• Synonym(e): β-Methylumbelliferone, 7-Hydroxy-4-methylcoumarin
• Lineare Formel: C₁₀H₇O₃Na
• CAS-Nummer: 5980-33-6
• Molekulargewicht: 198.15
• EG-Nummer: 227-790-1
• MDL-Nummer: MFCD00069856
• UNSPSC-Code: 12352204
• PubChem Substanz-ID: 24896658
• NACRES: NA.32

Eigenschaften

• product name: 4-Methylumbelliferone sodium salt, ≥98% (HPLC), crystalline
• Assay: ≥98% (HPLC)
• Form: crystalline
• Farbe: yellow
• Löslichkeit: water: 50 mg/mL
• SMILES String: [Na+].CC1=CC(=O)Oc2cc([O-])ccc12
• InChI: 1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
• InChIKey: JGMQHDNPUCPRQE-UHFFFAOYSA-M

Beschreibung

Allgemeine Beschreibung

4-methylumbelliferone (4-MU) is a coumarin derivative.

Anwendung

4-Methylumbelliferone sodium salt has been used:

• as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liver
• as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action
• in cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer

Biochem./physiol. Wirkung

4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)