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K1128

Sigma-Aldrich

α-Ketoglutarsäure

BioReagent, suitable for cell culture, suitable for insect cell culture

Synonym(e):

2-Oxo-glutarsäure, 2-Oxopentandisäure

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CHF 71.80
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CHF 222.00

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5 G
CHF 45.40
25 G
CHF 71.80
100 G
CHF 222.00

About This Item

Lineare Formel:
HOOCCH2CH2COCOOH
CAS-Nummer:
328-50-7
Molekulargewicht:
146.10
Beilstein:
1705689
EG-Nummer:
206-330-3
MDL-Nummer:
MFCD00004165
UNSPSC-Code:
12352204
PubChem Substanz-ID:
24896202
NACRES:
NA.32

CHF 45.40

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Produktlinie

BioReagent

Assay

≥98.5% NaOH basis (titration)

Form

powder or crystals

Methode(n)

cell culture | insect: suitable
cell culture | mammalian: suitable

Löslichkeit

water: 100 mg/mL, clear to slightly hazy, colorless to almost colorless

Lagertemp.

2-8°C

SMILES String

OC(=O)CCC(=O)C(O)=O

InChI

1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10)

InChIKey

KPGXRSRHYNQIFN-UHFFFAOYSA-N

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Allgemeine Beschreibung

Alpha-ketoglutarate (αKG), a vital intermediate in the tricarboxylic acid (TCA)/Krebs cycle, is located between succinyl-CoA and isocitrate.[1]

Anwendung

α-Ketoglutaric acid has been used:
  • as a supplement in minimum essential medium α (α-MEM) to culture primary mesenchymal stromal/stem cells (MSCs) to study its effects on age-related osteoporosis[1]
  • for chemical treatments to compare the treatment effects of several compounds on lifespan between manual and automated lifespan machine (ALM) platforms[2]
  • as a printed chemotaxis ligand to screen chemotaxis receptors with high-throughput technologies and verify the interactions with surface plasmon resonance (SPR)[3]

Biochem./physiol. Wirkung

Alpha-ketoglutarate (αKG), a nitrogen scavenger, is an important source of glutamate and glutamine.[4] It controls the synthesis of ATP and decreases the generation of equivalent (NAD+/NADH) in the tricarboxylic acid (TCA) cycle.[1] It promotes the synthesis of protein and prevents protein degradation in muscles. This immune nutrient factor participates in the general immune and collagen metabolism.[4] In aged rodents, αKG accelerates the healing of bone defects. It may possess potential anti-aging effects.[1] This Krebs cycle molecule can be used as a supplement in insect and mammalian cell cultures.

Piktogramme

Corrosion
GHS05

Signalwort

Danger

H-Sätze

H318

Gefahreneinstufungen

Eye Dam. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
BCCM6132
0000271298
BCCK7215
0000271298
BCCH3270

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Die Dokumentenbibliothek aufrufen

Nan Wu et al.
Biomolecules & therapeutics, 24(1), 1-8 (2016-01-14)
Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source of glutamate and glutamine that stimulates protein synthesis and inhibits
J Kitaura et al.
European journal of pediatrics, 158(5), 410-413 (1999-05-20)
Two cases of hyperinsulinaemic hypoglycaemia associated with persistent hyperammonaemia in unrelated infants of 7 days and 4 months of age are reported. Blood ammonia levels were 100-300 micromol/l (normal values <40 micromol/l). The hyperammonaemia was asymptomatic and not associated with
Christopher J Day et al.
Methods in molecular biology (Clifton, N.J.), 1729, 303-317 (2018-02-13)
Ligand-receptor interactions triggering signal transduction components of many sensory pathways, remain elusive due to paucity of high-throughput screening methods. Here we describe our use of small molecule microarrays comprising of small glycans, amino and organic acids, salts, and other known
Yuan Wang et al.
Nature communications, 11(1), 5596-5596 (2020-11-07)
Age-related osteoporosis is characterized by the deterioration in bone volume and strength, partly due to the dysfunction of bone marrow mesenchymal stromal/stem cells (MSCs) during aging. Alpha-ketoglutarate (αKG) is an essential intermediate in the tricarboxylic acid (TCA) cycle. Studies have
Kaiju Sun et al.
Theranostics, 11(12), 5831-5846 (2021-04-27)
Purpose: The implementation of targeted therapies for acute myeloid leukemia (AML) has been challenging. Fat mass and obesity associated protein (FTO), an mRNA N6-methyladenosine (m6A) demethylase, functions as an oncogene that promotes leukemic oncogene-mediated cell transformation and leukemogenesis. Here, we
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