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A4544

Sigma-Aldrich

L-Ascorbinsäure

suitable for cell culture, suitable for plant cell culture, ≥98%

Synonym(e):

L-Threoascorbinsäure, Anti-Scorbut-Faktor, Vitamin C

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25 G
CHF 42.50
100 G
CHF 89.20
500 G
CHF 251.00

CHF 42.50

Voraussichtliches Versanddatum14. März 2025

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25 G
CHF 42.50
100 G
CHF 89.20
500 G
CHF 251.00

About This Item

Empirische Formel (Hill-System):
C6H8O6
CAS-Nummer:
50-81-7
Molekulargewicht:
176.12
Beilstein:
84272
EG-Nummer:
200-066-2
MDL-Nummer:
MFCD00064328
UNSPSC-Code:
12352201
PubChem Substanz-ID:
24890875
NACRES:
NA.21

CHF 42.50

Voraussichtliches Versanddatum14. März 2025

Bulk-Bestellung anfordern

Qualitätsniveau

200

Assay

≥98%

Form

powder

Mol-Gew.

Mw 176.12 g/mol

Methode(n)

cell culture | mammalian: suitable
cell culture | plant: suitable

Farbe

white to light yellow

pH-Wert

1.0-2.5 (25 °C, 176 g/L in water)

mp (Schmelzpunkt)

190-194 °C (dec.)

Löslichkeit

water: soluble 50 mg/mL

SMILES String

OC([C@]([C@@H](O)CO)([H])O1)=C(O)C1=O

InChI

1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

InChIKey

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

Angaben zum Gen

human ... SLC23A2(9962)

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Allgemeine Beschreibung

L-ascorbic acid also called vitamin C, is a water soluble vitamin and acts as a reducing agent for various biochemical reactions. Ascorbic acid plays a key role in the production of collagen. Ascorbic acid is essential for neurodevelopment, neurotransmitter synthesis and modulates neuronal synapsis.[1] Dietary inadequacy of vitamin C has negative impact on cognition.[2]

Anwendung

L-ascorbic acid has been used as an ingredient in the basal medium for bovine mammary epithelial cells[3] and oocyte-granulosa cell complexes.[4] It has been used as a supplement in the osteogenic medium for osteogenic differentiation.[5][6]

Biochem./physiol. Wirkung

Ascorbic Acid, also known as Vitamin C, is a six-carbon lactone produced by plants and some animal species but not by humans and other primates. Ascorbic acid functions as an enzymatic cofactor for multiple enzymes, serving as an electron donor for monooxygenases and dioxygenases. Ascorbic acid also functions as a powerful antioxidant, particularly in regards to reactive oxygen species.

Sonstige Hinweise

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

The effect of mesenchymal stromal cells on the osseoinduction of impaction grafts
Korda M, et al.
Tissue Engineering: Part A, 16(2), 675-683 (2009)
Mitochondrial dysfunction of in vitro grown rabbit oocytes results in preimplantation embryo arrest after activation
Kanaya H, et al.
Journal of Reproduction and Development, 53(3), 631-637 (2007)
Multipotency and cardiomyogenic potential of human adipose-derived stem cells from epicardium, pericardium, and omentum
Wystrychowski W, et al.
Stem Cell Research & Therapy, 7(1), 84-84 (2016)
Vitamin C status and cognitive function: A systematic review
Travica N, et al.
Nutrients, 9(9), 960-960 (2017)
Does vitamin C deficiency affect cognitive development and function?
Hansen SN, et al.
Nutrients, 6(9), 3818-3846 (2014)
Alle zugehörigen Dokumente anzeigen

Artikel

Ascorbate in Cell Culture

Importance and uses of ascorbate in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. Can we store vitamin C solution (25mM) at -20 degree? In case for how many time it can be stored?

    1 answer

    1. The solution stability of this compound has not been determined, however it is subject to degradation when exposted to oxygen or alkaline pH conditions. As a general rule, avoid repeated freeze/thaw cycles. The publication below indicates that the material is stable when stored frozen in RPMI-1640 at -20°C.
      https://pubmed.ncbi.nlm.nih.gov/1698293/

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