Sigma-Aldrich tests the solubility of Product A8423, Amiodarone hydrochloride in water at a concentration of 50 mg/ml. This requires heating at 105 °C for 10 minutes. This concentration is above the solubility maximum at room temperature. As per the chemicals encyclopedia published by the Royal Society of Chemistry 13th Ed., Entry #482, solubility at 25 °C, (g/100mL): Water (0.07), Ethanol (1.28), Methanol (9.98), Chloroform (44.51), Methylene Chloride (19.2), and Hexane (0.03).Reportedly, the solubility of the product is 10 mg/ml each in DMSO and in dimethylformamide.
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A8423
Amiodaron -hydrochlorid
≥98% (TLC), powder, ion channel blocker
Synonym(e):
(2-Butyl-3-benzofuranyl)-[4-(2-diethylamino-ethoxy)-3,5-diiodphenyl]-keton -hydrochlorid, (2-Butyl-3-benzofuranyl)[4-[2-(diethylamino)-ethoxy]-3,5-diiod-phenyl]-methanon -hydrochlorid
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1 G
CHF 134.00
5 G
CHF 282.00
10 G
CHF 464.00
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1 G
CHF 134.00
5 G
CHF 282.00
10 G
CHF 464.00
About This Item
Empirische Formel (Hill-System):
C25H29I2NO3 · HCl
CAS-Nummer:
Molekulargewicht:
681.77
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77
Empfohlene Produkte
Produktbezeichnung
Amiodaron -hydrochlorid, ≥98%
Assay
≥98%
Form
powder
Ersteller
Wyeth
Lagertemp.
2-8°C
SMILES String
C(=O)(C=1C=2C(OC1CCCC)=CC=CC2)C3=CC(I)=C(OCCN(CC)CC)C(I)=C3.Cl
InChI
1S/C25H29I2NO3.ClH/c1-4-7-11-22-23(18-10-8-9-12-21(18)31-22)24(29)17-15-19(26)25(20(27)16-17)30-14-13-28(5-2)6-3;/h8-10,12,15-16H,4-7,11,13-14H2,1-3H3;1H
InChIKey
ITPDYQOUSLNIHG-UHFFFAOYSA-N
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Anwendung
Amiodarone hydrochloride has been used to study its interaction with cysteamine to stimulate autophagy in cultured biosensor cell lines.[1] It has also been used in larval and adult organ toxicogenomic screening to analyze the transcriptional effects of pharmaceuticals.[2]
Amiodarone hydrochloride is a non-selective ion channel blocker. Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death. Amiodarone hydrochloride has also been used in a study to determine concentrations of thyroid disrupting substances in effluents from wastewater treatment plants.
Biochem./physiol. Wirkung
Non-selective ion channel blocker. Amiodarone induces an immediate influx of Ca2+ in Saccharomyces cerevisiae, followed by mitochondrial fragmentation and cell death.
Leistungsmerkmale und Vorteile
This compound was developed by Wyeth. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Substrate
CYP2C8/9 and CYP3A family (minor pathway) inhibitor and substrate; CYP2D6, CYP3A family, CYP2D6, CYP2A6, CYP2B6 desethyl-form inhibitor
Signalwort
Warning
Gefahreneinstufungen
Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Eye Irrit. 2 - Lact. - Repr. 2 - Skin Irrit. 2 - STOT SE 3
Zielorgane
Respiratory system
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Persönliche Schutzausrüstung
dust mask type N95 (US), Eyeshields, Gloves
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Kunden haben sich ebenfalls angesehen
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Journal of environmental sciences (China), 23(4), 671-675 (2011-07-29)
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'Foamy' alveolar macrophages (FAM) observed in nonclinical toxicology studies during inhaled drug development may indicate drug-induced phospholipidosis, but can also derive from adaptive non-adverse mechanisms. Orally administered amiodarone is currently used as a model of pulmonary phospholipidosis and it was
Haruka Okamoto et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1051, 33-40 (2017-03-13)
Cationic amphiphilic drugs (CADs) can induce the hyperaccumulation of phospholipids in cells and tissues. This side effect, which is known as drug-induced phospholipidosis, is sometimes problematic in the development and clinical use of CADs. It is known that CADs generally
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What is the solubility of Product A8423, Amiodarone hydrochloride, and in which solvents may it be reconstituted?
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Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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