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90469

Sigma-Aldrich

(RS)-Mevalonsäure Lithiumsalz

≥96.0% (GC)

Synonym(e):

(±)-3,5-Dihydroxy-3-methyl-valeriansäure Lithiumsalz, (±)-MVA-Li, rac.-MVA-Li, Lithium-(±)-3,5-dihydroxy-3-methyl-pentanoat

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About This Item

Empirische Formel (Hill-System):
C6H11O4 · xLi+
CAS-Nummer:
150-97-0
Molekulargewicht:
147.15 (free acid basis)
MDL-Nummer:
MFCD00870420
UNSPSC-Code:
12352107
NACRES:
NA.25
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Qualität

for analytical purposes

Assay

≥96.0% (GC)

Form

solid

Zusammensetzung

lithium, 2.2-4.7%

Lagertemp.

2-8°C

SMILES String

OC(CCO)(CC(=O)O)C

InChI

1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)

InChIKey

KJTLQQUUPVSXIM-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Metabolit des Mevalonatweges, der eine wichtige Rolle in der Biosynthese von Sterolen, Dolichol, Häm und Ubichinon spielt. Von Interesse für Forschungen im Bereich der Onkologie, Autoimmunkrankheiten, Arteriosklerose und Alzheimer-Krankheit, sowie für angeborenen Mangel an Mevalonatkinase.

Verpackung

Bottomless glass bottle. Contents are inside inserted fused cone.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
BCCM5919
BCCH2669
BCCB1157
BCBN9252V
BCBF2487V

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Martin Thurnher et al.
Biochimica et biophysica acta, 1831(6), 1009-1015 (2013-03-26)
The mevalonate pathway is a highly conserved metabolic cascade and provides isoprenoid building blocks for the biosynthesis of vital cellular products such as cholesterol or prenyl pyrophosphates that serve as substrates for the posttranslational prenylation of numerous proteins. The pathway
Adelene Ai-Lian Song et al.
PloS one, 7(12), e52444-e52444 (2013-01-10)
Isoprenoids are a large and diverse group of metabolites with interesting properties such as flavour, fragrance and therapeutic properties. They are produced via two pathways, the mevalonate pathway or the 2-C-methyl-D-erythritol-4-phosphate (MEP) pathway. While plants are the richest source of
Ai Hosaka et al.
Neurochemical research, 38(3), 589-600 (2012-12-28)
Statins, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, have been reported to attenuate amyloid-β peptide (Aβ) production in various cellular models. However, the mechanisms by which statins affect neuronal Aβ production have not yet been clarified. Here, we investigated this issue in
Jordi Pérez-Gil et al.
The Biochemical journal, 452(1), 19-25 (2013-04-26)
Isoprenoids are a large family of compounds synthesized by all free-living organisms. In most bacteria, the common precursors of all isoprenoids are produced by the MEP (methylerythritol 4-phosphate) pathway. The MEP pathway is absent from archaea, fungi and animals (including
Jianxin Shi et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34(1), 429-435 (2012-11-28)
Esophageal squamous cell carcinoma (ESCC) is one of the most common lethal tumors in the world. Thus, it is very urgent to develop new therapeutic targets against this disease. The mevalonate (MVA) pathway, paced by its rate-limiting enzyme, hydroxymethylglutaryl coenzyme
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Questions

1–5 of 5 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. can you confirm the RS isomer relative composition of the mixed isomer product 90469?

    1 answer

    1. The compound is labeled as (±) or racemic meaning there are an equal mix of R and S isomers. However, there are no optical activity assays performed on the final product to verify the exact compositions of the R and S isomers.

      Helpful?

  4. Is there any information available regarding the solubility of (RS)-Mevalonic acid lithium salt, Catalog 90469, for resuspension purposes?

    1 answer

    1. The solubility of (RS)-Mevalonic acid lithium salt is as follows:
      1. In H2O: 100 mg/mL (648.97 mM; ultrasonic agitation required)
      2.In DMSO: 50 mg/mL (324.49 mM; ultrasonic agitation required)

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  5. What is the recommended solution to dissolve this product in if wanting to add to cell culture media?

    1 answer

    1. This product is not tested for solubility. However various sources state that compound is soluble in water and PBS (may require sonication), as well as DMSO.

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