32473

Metoclopramid

VETRANAL^®, analytical standard

• Synonym(e): 4-Amino-5-chlor-N-[2-(diethylamino)-ethyl]-2-methoxy-benzamid, Methoxychlorprocainamid
• Empirische Formel (Hill-System): C₁₄H₂₂ClN₃O₂
• CAS-Nummer: 364-62-5
• Molekulargewicht: 299.80
• Beilstein: 1884366
• EG-Nummer: 206-662-9
• MDL-Nummer: MFCD00211338
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329754232
• NACRES: NA.24

Eigenschaften

• Qualität: analytical standard
• Qualitätsniveau: 100
• Produktlinie: VETRANAL^®
• Haltbarkeit: limited shelf life, expiry date on the label
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• Anwendung(en): forensics and toxicology; pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: CCN(CC)CCNC(=O)c1cc(Cl)c(N)cc1OC
• InChI: 1S/C14H22ClN3O2/c1-4-18(5-2)7-6-17-14(19)10-8-11(15)12(16)9-13(10)20-3/h8-9H,4-7,16H2,1-3H3,(H,17,19)
• InChIKey: TTWJBBZEZQICBI-UHFFFAOYSA-N
• Angaben zum Gen: human ... DRD2(1813) , HTR3A(3359) , HTR4(3360)

Beschreibung

Allgemeine Beschreibung

Metoclopramide is a drug, which can be effective in the treatment of severe nausea and vomiting caused by the anticancer drug cis-platinum.[1]

Metoclopramide is typically employed as an antiemetic drug or a gastrointestinal prokinetic drug in adults and children.[2]

Anwendung

Metoclopramide may be used as a reference standard for the determination of the analyte in serum samples using reversed-phase high-performance liquid chromatography (RP-HPLC) with electrochemical detection.[3]

Metoclopramide may be used as an analytical reference standard for the determination of the analyte in:

• Human plasma by liquid–liquid extraction (LLE) with dichloromethane followed by hydrophilic interaction chromatography-electrospray iionization-tandem mass spectrometry (HILIC-ESI-MS/MS) operating in selected reaction monitoring (SRM) mode of detection.[4]

It may also be used as an internal standard for the determination of loratadine and desloratadine in:

• Human plasma by high performance liquid chromatography (HPLC) coupled to MS/MS with multiple reaction monitoring (MRM) detection.[5]

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Rechtliche Hinweise

VETRANAL is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1