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Merck

764213

Sigma-Aldrich

Biotin-PEG4-alkyne

for copper catalyzed click labeling

Synonym(e):

Polyethylene glycol, Acetylene-PEG4-biotin conjugate

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About This Item

Empirische Formel (Hill-System):
C21H35N3O6S
CAS-Nummer:
Molekulargewicht:
457.58
UNSPSC-Code:
12161502
PubChem Substanz-ID:
NACRES:
NA.22

Assay

95%

Form

solid

Eignung der Reaktion

reaction type: click chemistry

mp (Schmelzpunkt)

55-64 °C

Lagertemp.

−20°C

SMILES String

O=C(NCCOCCOCCOCCOCC#C)CCCC[C@@H](SC1)[C@@]2([H])[C@]1([H])NC(N2)=O

InChI

1S/C21H35N3O6S/c1-2-8-27-10-12-29-14-15-30-13-11-28-9-7-22-19(25)6-4-3-5-18-20-17(16-31-18)23-21(26)24-20/h1,17-18,20H,3-16H2,(H,22,25)(H2,23,24,26)/t17-,18-,20-/m1/s1

InChIKey

SKMJWNZZFUDLKQ-QWFCFKBJSA-N

Anwendung

Biotin-PEG4-alkyne may be used for the modification of 4-azidophenylalanine (AzPhe) silk fibroin via bioorthogonal azide–alkyne cycloaddition reaction for developing photopatternable protein material.
Biotinylation reagent for labeling azide containing molecules or biomolecules using copper-catalyzed 1,3 dipolar cycloaddition click chemistry. The alkyne group reacts with azides to form a stable triazole linkage, facilitating the introduction of biotin into your azide modified system of interest.

Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002)

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Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Ryan T Cassell et al.
Chembiochem : a European journal of chemical biology, 16(7), 1060-1067 (2015-04-01)
The brevetoxins are neurotoxins that are produced by the "Florida red tide" dinoflagellate Karenia brevis. They bind to and activate the voltage-gated sodium channels in higher organisms, specifically the Nav 1.4 and Nav 1.5 channel subtypes. However, the native physiological
Javier Mazuela et al.
Organic letters, 19(20), 5541-5544 (2017-10-06)
The organocatalytic asymmetric transfer hydrogenation of N-alkyl aryl imino esters for the direct synthesis of N-alkylated arylglycinate esters is reported. High yields and enantiomeric ratios were obtained, and tolerance to a diverse set of functional groups facilitated the preparation of
Azide-incorporated clickable silk fibroin materials with the ability to photopattern.
Teramoto H, et al.
ACS biomaterials science & engineering, 2(2), 251-258 (2016)
Maheshika S K Wanigasekara et al.
ACS omega, 3(10), 14229-14235 (2019-08-29)
Modification of arginine residues using dicarbonyl compounds is a common method to identify functional or reactive arginine residues in proteins. Arginine undergoes several kinds of posttranslational modifications in these functional residues. Identifying these reactive residues confidently in a protein or
Nrf1 can be processed and activated in a proteasome-independent manner.
Vangala JR, et al.
Current Biology, 26(18), R834-R835 (2016)

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