- Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles.
Synthesis, antioxidant properties and radioprotective effects of new benzothiazoles and thiadiazoles.
Bioorganic & medicinal chemistry (2009-06-09)
Damien Cressier, Caroline Prouillac, Pierre Hernandez, Christine Amourette, Michel Diserbo, Claude Lion, Ghassoub Rima
PMID19502068
RESUMO
In this work, we report the synthesis and characterization of new compounds derived from benzothiazoles and thiadiazoles. We observed that structural modifications on these skeletons affected the antioxidant activity. Thiol and aminothiol compounds derived from thiadiazoles and benzothiazoles showed an interesting antioxidant property. The radioprotective activity has also been evaluated in mice. Some of these compounds could be good radioprotectors.
MATERIAIS
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Sigma-Aldrich
Ácido L-ascórbico, suitable for cell culture, suitable for plant cell culture, ≥98%
Sigma-Aldrich
Ácido L-ascórbico, puriss. p.a., ACS reagent, reag. ISO, Ph. Eur., 99.7-100.5% (oxidimetric)