SML3989

DRP1 Inhibitor, MIDI

≥98% (HPLC)

• Sinônimo(s): 1,1′-(1,4-Phenylene)bis[3-(3-pyridinyl)-2-propen-1-one], MIDI
• Fórmula empírica (Notação de Hill): C₂₂H₁₆N₂O₂
• Número CAS: 348145-43-7
• Peso molecular: 340.37
• Código UNSPSC: 12352200

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 0.5 mg/mL, clear (Warmed)
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: O=C(/C=C/C1=CC=CN=C1)C2=CC=C(C(/C=C/C3=CC=CN=C3)=O)C=C2
• chave InChI: IOESTAVFGVAMRH-YDWXAUTNSA-N

Descrição

Ações bioquímicas/fisiológicas

Mitochondrial fission inhibitor that blocks DRP1 recruitment to mitochondria.



DRP1 Inhibitor MIDI is a cell-permeable, symmetrical pyridinyl-propenone compound that acts as a potent, time-dependent mitochondrial fission inhibitor (0.5 - 2 µM) and functionally mimics DRP1 knockout. MIDI is shown to covalently interact with DRP1-C367 and disrupt DRP1 interaction with its mitochondrial receptors MFF and MiD49/51. Blocks stress-induced mitochondrial fragmentation and promotes mitochondrial hyperfusion. MIDI does neither obstruct DRP1 tetramerization nor its GTPase activity. Poorly affects mitochondrial oxygen consumption rate and glycolysis activity.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable