SML2234

1S,3R-RSL 3

≥98% (HPLC), powder, GPx4 inhibitor

• Sinônimo(s): RAS-selective lethal, RSL3, (1S, 3R)-2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester
• Fórmula empírica (Notação de Hill): C₂₃H₂₁ClN₂O₅
• Número CAS: 1219810-16-8
• Peso molecular: 440.88
• Número MDL: MFCD30187526
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nome do produto: 1S,3R-RSL 3, ≥98% (HPLC)
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• atividade óptica: [α]/D 9.0 to 15.0°, c = 0.5 in methanol
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: ClCC(=O)N1[C@H](Cc2c3c([nH]c2[C@@H]1c4ccc(cc4)C(=O)OC)cccc3)C(=O)OC
• chave InChI: TXJZRSRTYPUYRW-NQIIRXRSSA-N

Descrição

Descrição geral

Ras-selective lethal small molecule 3 (RSL3) induces ferroptosis by inhibiting the activity of glutathione peroxidase 4 (GPx4)[1]. RSL3 not only activates ferroptosis but also blocks the activation of the mammalian target of rapamycin (mTOR) signaling pathway through interactions with GPX4. In thyroid cancer cell lines, RSL3 decreases cell viability, inhibits spheroid formation, and disrupts cell migration in vitro.[2]

Aplicação

1S,3R-RSL 3 has been used:

• as a glutathione peroxidase 4 (GPX4) inhibitor to study its effects on cell death in subventricular glioblastoma multiforme (GBM) lines[3]
• GPX4 inhibitor and ferroptosis inducer to study its effects on cardiomyocyte death and heart failure in mice[4]
• as a ferroptosis inducer in HT-1080 cellsin cell viability assay[5]

Ações bioquímicas/fisiológicas

Ferroptosis inducer; inhibits glutathione peroxidase 4 (GPX4)

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable