V116

Z-VAD-FMK

≥98% (TLC), solid, Caspase inhibitor

• Sinônimo(s): N-Benzyloxycarbonyl-Val-Ala-Asp(O-Me) fluoromethyl ketone
• Fórmula empírica (Notação de Hill): C₂₂H₃₀FN₃O₇
• Número CAS: 187389-52-2
• Peso molecular: 467.49
• Número MDL: MFCD01074990
• Código UNSPSC: 12352209
• NACRES: NA.77

Propriedades

• Nome do produto: Z-VAD-FMK, solid
• fonte biológica: synthetic
• Ensaio: ≥98% (TLC)
• Formulário: solid
• cor: white
• solubilidade: DMSO: 20 mg/mL; H₂O: insoluble
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: FCC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C)C)CC(=O)OC
• InChI: 1S/C22H30FN3O7/c1-13(2)19(26-22(31)33-12-15-8-6-5-7-9-15)21(30)24-14(3)20(29)25-16(17(27)11-23)10-18(28)32-4/h5-9,13-14,16,19H,10-12H2,1-4H3,(H,24,30)(H,25,29)(H,26,31)/t14-,16-,19-/m0/s1
• chave InChI: MIFGOLAMNLSLGH-QOKNQOGYSA-N
• Informações sobre genes: human ... CASP3(836) ; mouse ... CASP3(12367) ; rat ... CASP3(25402)

Descrição

Descrição geral

Z-VAD-FMK inhibits yeast and mammalian peptide N-glycanase (PNGase).[1] It induces apoptosis. Z-VAD-FMK might be associated with endoplasmic reticulum (ER) stress.[2]

Aplicação

Z-VAD-FMK has been used:

• to induce mixed-lineage kinase domain-like (MLKL) phosphorylation (p-MLKL) in L929 cells[3]
• to induce autophagy in Jurkat and K562 cells[4]
• to revert killing effects of oxaliplatin or oxaliplatin combination with chloroquine (CQ) on HCT116 and SW620 cell lines[5]
• as a caspase inhibitor to inhibit apoptosis and assess nuclear factor-kB, heat shock protein 70 (Hsp 70), proto-oncogene (cmyc) and tumor suppressor protein p53[6]

Ações bioquímicas/fisiológicas

Non-selective, cell permeable inhibitor of caspase-1- and caspase-3-related proteases.

Características e benefícios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Embalagem

Bottomless glass bottle. Contents are inside inserted fused cone.

Atenção

Hygroscopic

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)