B2515

L-Buthionine-sulfoximine

≥97% (TLC)

• Sinônimo(s): L-BSO
• Fórmula empírica (Notação de Hill): C₈H₁₈N₂O₃S
• Número CAS: 83730-53-4
• Peso molecular: 222.31
• Beilstein: 2367136
• Número MDL: MFCD00067000
• Código UNSPSC: 12352202
• ID de substância PubChem: 24278263
• NACRES: NA.77

Propriedades

• fonte biológica: synthetic (organic)
• Ensaio: ≥97% (TLC)
• forma: powder
• pf: 224-226 °C
• solubilidade: water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: CCCCS(=N)(=O)CC[C@H](N)C(O)=O
• InChI: 1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)/t7-,14?/m0/s1
• chave InChI: KJQFBVYMGADDTQ-CVSPRKDYSA-N
• Informações sobre genes: human ... GCLC(2729) , GCLM(2730)

Descrição

Aplicação

L-Buthionine-sulfoximine has been used:

• as a selective activator for the induction of ferroptosis in rat apoptotic cells
• as an inhibitor of γ-glutamylcysteine synthetase to study its effects on the viability and effectiveness of microspore embryogenesis (ME) induction in triticale and barley
• as a glutathione synthesis blocker to study its effects on auranofin (AFN)-mediated interleukin-1β expression in murine alveolar macrophages

Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

Ações bioquímicas/fisiológicas

Blocks cellular resistance to chemotherapy by inhibiting γ-glutamylcysteine synthetase, a key enzyme in glutathione biosynthesis. Used to induce experimental glutathione deficiency, to investigate roles of glutathione in cellular processes.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)