This product is lyophilized from a solution containing sodium glutamate and human serum albumin. The material may be reconstituted in water. For assay purposes, this material is reconstituted in 10 mM Tris-HCl / 0.1 M NaCl / 0.1% BSA, pH 7.4 . The solution stability has not been determined.
S3134
Streptokinase from β-hemolytic Streptococcus (Lancefield Group C)
lyophilized powder, ≥2,000 units/mg solid
Sinônimo(s):
Streptokinase from Streptococcus hemolyticus
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R$ 502,00
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10000 UNITS
R$ 502,00
50000 UNITS
R$ 1.656,00
250000 UNITS
R$ 5.693,00
About This Item
R$ 502,00
Check Cart for Availability
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Formulário
lyophilized powder
atividade específica
≥2,000 units/mg solid
Condições de expedição
wet ice
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
N1C(CC(C1)C2CCCCC2)C(=O)O
InChI
1S/C11H19NO2/c13-11(14)10-6-9(7-12-10)8-4-2-1-3-5-8/h8-10,12H,1-7H2,(H,13,14)
chave InChI
XRZWVSXEDRYQGC-UHFFFAOYSA-N
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Descrição geral
Research area: Cell signaling
Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.[1]
Streptokinase is an extracellular enzyme produced by β-hemolytic Streptococcus. It is a single-chain polypeptide enzyme that consists of multiple structural domains, including α-, β-, and γ-domains.[1]
Aplicação
Streptokinase has been used in a study to compare primary coronary intervention and thrombolytic therapy in myocardial infarction patients. [2]
Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare.
Ações bioquímicas/fisiológicas
Streptokinase is a potent plasminogen activator. Unlike human proteins tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), microbial streptokinase does not directly activate plasminogen. Instead, it activates plasminogen by fibrin-dependent and fibrin-independent. mechanisms.[1] Streptokinase is effective in thrombolytic therapy.[1] While streptokinase offers promising potential in treating ischemic stroke, its use also presents a significant risk of intracerebral hemorrhage. Streptokinase is also used in treating complicated parapneumonic effusions and empyema where allergic reactions, are rare.[3]
Definição da unidade
One unit is equal to the amount of activity in one unit from a Streptokinase International Standard reference vial.
forma física
Lyophilized powder containing ~50% total protein by biuret and sodium glutamate. Total protein composed of enzyme protein and human serum albumin.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Streptokinase--a clinically useful thrombolytic agent
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Streptokinase--a clinically useful thrombolytic agent
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Staphylokinase, a fibrin-specific plasminogen activator with therapeutic potential?
D Collen et al.
Blood, 84(3), 680-686 (1994-08-01)
Primary coronary intervention versus thrombolytic therapy in myocardial infarction patients in the Middle East
Al-Zakwani, I., et al.
Journal of the American Medical Association, 34(3), 445-451 (2012)
Ansar S Zhalyalov et al.
PloS one, 12(7), e0180668-e0180668 (2017-07-08)
Fibrinolysis is a cascade of proteolytic reactions occurring in blood and soft tissues, which functions to disintegrate fibrin clots when they are no more needed. In order to elucidate its regulation in space and time, fibrinolysis was investigated using an
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