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S2876

Sigma-Aldrich

Spermine tetrahydrochloride

Spermine tetrahydrochloride

powder or crystals, NMDA agonist/antagonist

Sinônimo(s):

N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

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1 G
R$ 482,00
5 G
R$ 2.033,00
10 G
R$ 3.915,00
25 G
R$ 7.011,00
100 G
R$ 22.683,00

R$ 482,00

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1 G
R$ 482,00
5 G
R$ 2.033,00
10 G
R$ 3.915,00
25 G
R$ 7.011,00
100 G
R$ 22.683,00

About This Item

Fórmula empírica (Notação de Hill):
C10H26N4 · 4HCl
Número CAS:
306-67-2
Peso molecular:
348.18
Beilstein:
3911771
Número CE:
206-189-8
Número MDL:
MFCD00012914
Código UNSPSC:
12352200
ID de substância PubChem:
24278007
NACRES:
NA.77

R$ 482,00

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Nome do produto

Spermine tetrahydrochloride, powder or crystals

Formulário

powder or crystals

pf

310-311 °C (dec.) (lit.)

solubilidade

water, high purity: 100 mg/ml

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

chave InChI

XLDKUDAXZWHPFH-UHFFFAOYSA-N

Informações sobre genes

human ... GRIN1(2902)

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Aplicação

Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue,[1] archival tissue of salivary gland, renal and thyroid tumors[2] and red blood cells of chicken.[3]
Used to precipitate DNA from low salt aqueous buffers.

Ações bioquímicas/fisiológicas

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Spermine, a polyamine, is derived from spermidine and is required for cell growth in eukaryotes. It acts as regulator of gene expression, inhibits DNA damage and protects the cells from damage by acting as free radical scavenger.[4][5] In proteomics studies, spermine mediates rapid crystallization of DNA-binding proteins.[6]

Nota de preparo

Spermine tetrahydrochloride yields clear, colorless to light yellow solution in water at 100 mg/ml.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
BCCM3591
BCCM4262
BCCK4900
0000270933
0000270931

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Spermidine trihydrochloride ≥99.0% (AT)

SAFC

85580

Spermidine trihydrochloride

Putrescine dihydrochloride ≥98% (TLC)

Sigma-Aldrich

P7505

Putrescine dihydrochloride

Spermidine phosphate salt hexahydrate

Sigma-Aldrich

S0381

Spermidine phosphate salt hexahydrate

Spermine analytical standard

Supelco

55513

Spermine

A S Jackson et al.
The British journal of nutrition, 40(3), 497-504 (1978-11-01)
1. Skinfold thickness, body circumferences and body density were measured in samples of 308 and ninety-five adult men ranging in age from 18 to 61 years. 2. Using the sample of 308 men, multiple regression equations were calculated to estimate
E Bergers et al.
Journal of clinical pathology, 49(11), 931-937 (1996-11-01)
Conflicting results have been reported concerning the prognostic value of DNA flow cytometric variables (DNA ploidy, DNA index, %S phase fraction) in breast cancer. Selection bias and differences in treatment may have contributed to these conflicting prognostic results. Differences in
L L Vindeløv et al.
Cytometry, 3(5), 323-327 (1983-03-01)
A new modification of our detergent technique for the preparation of nuclei for flow cytometric DNA analysis is described. The attainment of low coefficients of variation of the peaks and of quantitative staining of nuclei from different tissues was a
H C Ha et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(19), 11140-11145 (1998-09-16)
The polyamines are small organic cations that are absolutely required for eukaryotic cell growth. Although their growth requirements are well established, the molecular functions of the polyamines are ill-defined. Oxidative damage to DNA by reactive oxygen species is a continual
J Griffith et al.
Biochemistry, 24(1), 158-162 (1985-01-01)
The RecA protein of Escherichia coli, whether pure or in a crude cell lysate, will rapidly form small crystals (microcrystals) in the presence of low concentrations of spermidine. We describe the conditions of time, pH, and polyamine concentration over which
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