S4264
Spermine
BioReagent, suitable for cell culture
Sinônimo(s):
N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine
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1 G
R$ 544,00
5 G
R$ 1.942,00
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1 G
R$ 544,00
5 G
R$ 1.942,00
About This Item
Fórmula linear:
NH2(CH2)3NH(CH2)4NH(CH2)3NH2
Número CAS:
Peso molecular:
202.34
Beilstein:
1750791
Número CE:
Número MDL:
Código UNSPSC:
12352204
ID de substância PubChem:
NACRES:
NA.75
Produtos recomendados
fonte biológica
microbial
synthetic
linha de produto
BioReagent
Ensaio
≥96%
Formulário
solid
técnica(s)
cell culture | mammalian: suitable
p.e.
150 °C/5 mmHg (lit.)
pf
28-30 (lit.)
solubilidade
H2O: 50 mg/mL
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
[H]N(CCCN)CCCCN([H])CCCN
InChI
1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
chave InChI
PFNFFQXMRSDOHW-UHFFFAOYSA-N
Informações sobre genes
human ... GRIN2B(2904)
rat ... Grin2a(24409)
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Aplicação
Spermine has been used:
- in the buffer, to swap the divalent cations in the MgSO4 protocol to stabilize the integrity of the chromosomes[1]
- in the preparation of modified mica surfaces from freshly cleaved mica surfaces[2]
- to study its effects on survival in mice with sepsis and to estimate the role of spermine in lethal systemic inflammatory diseases[3]
Ações bioquímicas/fisiológicas
Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Spermine together with putrescine and spermidine compose a family of polyamines (polycations) that are required for the growth and survival of the vast majority of living cells. Polyamines interact with negatively charged molecules such as proteoglycans, glycated proteins and nucleic acids (DNA and RNA). Biogenic polyamines are found to modulate protein synthesis at different levels. This effect may be explained by the ability of polyamines to bind and influence the secondary structure of tRNA, mRNA, and rRNA. Spermine also helps stabilize nucleic acid helical structure and the conformation of glycated proteins such as the histones. Spermine and spermidine are components of various nucleic acid transfection protocols.
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).
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Nº do produto
Descrição
Preços
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Eye Dam. 1 - Skin Corr. 1B
Código de classe de armazenamento
8A - Combustible corrosive hazardous materials
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Fractionation of chromosome 15 with an affinity-based approach using magnetic beads
Vitharana S N and Wilson G S
Genomics, 87(1), 158-164 (2006)
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Journal of Immunology, 178(5), 3016-3022 (2007)
Miyuki Murata et al.
Current eye research, 42(12), 1674-1683 (2017-09-25)
Purpose/Aim of the study: To explore the possible role of vascular adhesion protein-1 (VAP-1) via its enzymatic function as a semicarbazide-sensitive amine oxidase (SSAO) in the pathogenesis of proliferative diabetic retinopathy (PDR). The levels of soluble VAP-1/SSAO and the unsaturated
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Asthma is a heterologous disease that is influenced by complex interactions between multiple environmental exposures, metabolism, and host immunoregulatory processes. Specific metabolites are increasingly recognized to influence respiratory inflammation. However, the role of protein-derived metabolites in regulating inflammatory responses in
H Hosseinkhani et al.
Gene therapy, 11(2), 194-203 (2004-01-09)
Dextran-spermine cationic polysaccharide was prepared by means of reductive amination between oxidized dextran and the natural oligoamine spermine. The formed Schiff-base imine-based conjugate was reduced with borohydride to obtain the stable amine-based conjugate. The transfection efficiency of the synthetic dextran-spermine
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