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M8750

Sigma-Aldrich

(+)-Methamphetamine hydrochloride

Sinônimo(s):

d-Desoxyephedrine hydrochloride, d-N,α-Dimethylphenethylamine hydrochloride, Methylamphetamine hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C10H15N · HCl
Número CAS:
51-57-0
Peso molecular:
185.69
Número CE:
200-106-9
Número MDL:
MFCD00056130
Código UNSPSC:
12352116
ID de substância PubChem:
24897282
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.

controle de medicamentos

USDEA Schedule II; Home Office Schedule 2; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IIB (Portugal)

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

solubilidade

H2O: soluble
ethanol: soluble

aplicação(ões)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

originador

Teva

cadeia de caracteres SMILES

Cl[H].CN[C@@H](C)Cc1ccccc1

InChI

1S/C10H15N.ClH/c1-9(11-2)8-10-6-4-3-5-7-10;/h3-7,9,11H,8H2,1-2H3;1H/t9-;/m0./s1

chave InChI

TWXDDNPPQUTEOV-FVGYRXGTSA-N

Informações sobre genes

human ... SLC6A2(6530) , SLC6A3(6531) , SLC6A4(6532)

Procurando produtos similares? Visita Guia de comparação de produtos

Categorias relacionadas

Ações bioquímicas/fisiológicas

Sympathomimetic with more potent central effects than amphetamine. It is transported into terminals via the monoamine transporters and induces release of dopamine, norepinephrine, epinephrine, and serotonin. Dopamine release is important for the addictive properties of methamphetamine while norepinephrine and epinephrine release are important for the cardiovascular effects. Serotonin neurotoxin.

Características e benefícios

This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Outras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H300,H336

Declarações de precaução

P301 + P310 + P330

Classificações de perigo

Acute Tox. 2 Oral - STOT SE 3

Órgãos-alvo

Central nervous system

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análise (COA)

Lot/Batch Number
SLCL6640
SLCC8107
SLBS1221V
SLBT1207
SLBV9808

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A M Stafford et al.
Psychopharmacology, 237(11), 3315-3336 (2020-08-25)
Genetic and non-genetic factors influence substance use disorders. Our previous work in genetic mouse models focused on genetic factors that influence methamphetamine (MA) intake. The current research examined several non-genetic factors for their potential influence on this trait. We examined
Noémie Cresto et al.
International journal of molecular sciences, 22(13) (2021-07-03)
Alpha-synuclein (α-syn) and leucine-rich repeat kinase 2 (LRRK2) play crucial roles in Parkinson's disease (PD). They may functionally interact to induce the degeneration of dopaminergic (DA) neurons via mechanisms that are not yet fully understood. We previously showed that the
G J Rivière et al.
The Journal of pharmacology and experimental therapeutics, 291(3), 1220-1226 (1999-11-24)
The purpose of these studies was to better understand the behavioral effects and pharmacokinetics of an i.v. bolus dose of (+)-methamphetamine [(+)-METH] in a rat model of (+)-METH abuse. We characterized the behavioral effects after increasing (+)-METH doses (0.1, 0.3
Leila Rezaeian et al.
Iranian journal of basic medical sciences, 23(11), 1480-1488 (2020-11-26)
This research aimed at evaluating the effect of berberine hydrochloride on anxiety-related behaviors induced by methamphetamine (METH) in rats, assessing relapse and neuroprotective effects. 27 male Wistar rats were randomly assigned into groups of Control, METH-withdrawal (METH addiction and subsequent
Arkadiusz Liśkiewicz et al.
Brain, behavior, and immunity, 80, 247-254 (2019-03-20)
Methamphetamine (METH) abusers are prone to develop a variety of comorbidities, including cognitive disabilities, and the immunological responses have been recognized as an important component involved in the toxicity of this drug. Cytokines are among the key mediators between systemic
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