The product is tested for solubility at 50 mg/ml in water. This information can be found in the specification sheet or Certificate of Analysis accessible from the Product Detail Page.
P6126
(R)-(−)-Phenylephrine hydrochloride
≥99% (titration), powder, α₁-adrenoceptor agonist
Sinônimo(s):
(R)-(−)-1-(3-Hydroxyphenyl)-2-methylaminoethanol hydrochloride, (R)-(−)-3-Hydroxy-α-(methylaminomethyl)benzyl alcohol hydrochloride
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About This Item
Fórmula linear:
HOC6H4CH(CH2NHCH3)OH·HCl
Número CAS:
Peso molecular:
203.67
Beilstein:
4158948
Número CE:
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.
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Nome do produto
(R)-(−)-Phenylephrine hydrochloride, powder
Formulário
powder
Nível de qualidade
pf
143-145 °C (lit.)
originador
Johnson & Johnson
cadeia de caracteres SMILES
OC1=CC([C@H](CNC)O)=CC=C1.Cl
InChI
1S/C9H13NO2.ClH/c1-10-6-9(12)7-3-2-4-8(11)5-7;/h2-5,9-12H,6H2,1H3;1H/t9-;/m0./s1
chave InChI
OCYSGIYOVXAGKQ-FVGYRXGTSA-N
Informações sobre genes
human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146)
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Descrição geral
(R)-(-)-Phenylephrine hydrochloride is an adrenergic agent, which functions as a β-receptor sympathomimetic drug.[1]
Aplicação
(R)-(-)-Phenylephrine hydrochloride has been used:
- in the preparation and culturing of cardiocytes and fibroblasts[2]
- to stimulate myocardial strips to measure slice contraction[3]
- in primary cardiomyocyte culture to show the effect of Kruppel-like factors (KLF) on cardiac hypertrophy in vivo[4]
- to evaluate the pharmacological response of embryonic stem cell (ESC)-derived cardiomyocytes[5]
- to pharmacologically rescue GATA (erythroid transcription factor) binding protein 3 (GATA3) null embryo from early embryonic lethality[6]
Ações bioquímicas/fisiológicas
α1-adrenoceptor agonist.
Características e benefícios
This compound is featured on the α1-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Aplicação
Nº do produto
Descrição
Preços
Palavra indicadora
Warning
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 4 Oral - Skin Sens. 1B
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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Certificados de análise (COA)
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Enantioselective synthesis of (R)-phenylephrine hydrochloride
Pandey RK, et al.
Tetrahedron Letters, 44(33), 6245-6246 (2003)
Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1
Bhavsar PK, et al.
Journal of Cardiovascular Translational Research, 3(6), 688-695 (2010)
A myocardial slice culture model reveals alpha-1A-adrenergic receptor signaling in the human heart
Thomas RC, et al.
JACC. Basic to translational science, 1(3), 155-167 (2016)
Effect of basic fibroblast growth factor on cardiomyocyte differentiation from mouse embryonic stem cells.
Khezri S, et al.
Saudi Medical Journal, 28(2), 181-186 (2007)
Proper development of the outer longitudinal smooth muscle of the mouse pylorus requires Nkx2-5 and Gata3
Udager AM, et al.
Gastroenterology, 146(1), 157-165 (2014)
Artigos
Review alpha 1 adrenoceptors as well as their agonists, antagonists, and tissue expression patterns. We suggest several modulators and alternatives for working with a-1 adrenoreceptors.
Chromatograms
application for HPLC-
How to dissolve the power of PE.
1 answer-
Helpful?
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Is (R)-(-)-Phenylephrine hydrochloride the same as L-Phenylephrine hydrochloride?
1 answer-
(R)-(-)-Phenylephrine hydrochloride is also named l-Phenylephrine hydrochloride (lower case el) or Levophenylephrine hydrochloride.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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