A6625

Acetylcholine chloride

≥99% (TLC)

• Sinônimo(s): ACh
• Fórmula linear: (CH₃)₃N⁺CH₂CH₂OCOCH₃Cl^-
• Número CAS: 60-31-1
• Peso molecular: 181.66
• Beilstein: 3571875
• Número CE: 200-468-8
• Número MDL: MFCD00011698
• Código UNSPSC: 51151535
• ID de substância PubChem: 57653875
• NACRES: NA.25

Propriedades

• Ensaio: ≥99% (TLC)
• pf: 146-150 °C (lit.)
• solubilidade: H₂O: 100 mg/mL
• cadeia de caracteres SMILES: [Cl-].CC(=O)OCC[N+](C)(C)C
• InChI: 1S/C7H16NO2.ClH/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
• chave InChI: JUGOREOARAHOCO-UHFFFAOYSA-M
• Informações sobre genes: human ... CHRM3(1131)

Descrição

Descrição geral

Acetylcholine is a neurotransmitter released at nerve endings in both the central and peripheral nervous systems. Acetylcholine chloride (C7H16ClNO2) is a stable cholinergic agonist with muscarinic and nicotinic actions. It is available as white or off-white hygroscopic crystals, or as a crystalline powder. Acetylcholine chloride is hygroscopic in nature and is highly soluble in water, alcohol, propylene glycol and chloroform.

Aplicação

Acetylcholine chloride has been used:

• as an agent to trigger sudomotor axon reflex response during autonomic test
• to induce contraction amplitude of pyloric circular smooth muscle strip (PCSMS) in rats
• as a substrate for acetylcholinesterase
• to stimulate after discharge in Aplysia bag cell neurons

Ações bioquímicas/fisiológicas

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Atenção

Very hygroscopic

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves