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G8173

Sigma-Aldrich

GW833972A

≥98% (HPLC), powder

Sinônimo(s):

2-[(3-chlorophenyl)amino]-N-(4-pyridinylmethyl)-4-(trifluoromethyl)-5-Pyrimidinecarboxamide hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C18H13ClF3N5O · HCl
Número CAS:
1092502-33-4
Peso molecular:
444.24
Número MDL:
MFCD18452844
Código UNSPSC:
12352200
ID de substância PubChem:
329799976
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

powder

controle de medicamentos

regulated under CDSA - not available from Sigma-Aldrich Canada

condição de armazenamento

desiccated

cor

off-white to light brown

solubilidade

DMSO: ≥20 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Cl.FC(F)(F)c1nc(Nc2cccc(Cl)c2)ncc1C(=O)NCc3ccncc3

InChI

1S/C18H13ClF3N5O.ClH/c19-12-2-1-3-13(8-12)26-17-25-10-14(15(27-17)18(20,21)22)16(28)24-9-11-4-6-23-7-5-11;/h1-8,10H,9H2,(H,24,28)(H,25,26,27);1H

chave InChI

UBHSVFAUAKIVKL-UHFFFAOYSA-N

Aplicação

GW833972A, a selective CB2 cannabinoid receptor agonist, may be used separately or in comparison to other cannabinoid receptor agonist and antagonists to differentiate and characterize the CB2 cannabinoid receptor. GW833972A may be used to help verify that an observed physiological response is cannabinoid receptor CB2-dependent.

Ações bioquímicas/fisiológicas

GW833972A is a CB2 cannabinoid receptor agonist with 1000-fold selectivity relative to CB1. It is, however, 15-fold less potent than HU210 for CB2 (Ki 7.8 vs. 0.52 nM). The antitumor compound oxaliplatin induces marked hypersensitivity to cold, heat, and chemical pain stimuli (to the point where oxaliplatin therapy has to be discontinued). The hyperalgesia effect is almost completely blocked by pretreatment with GW833972A.
The compound was used to determine the role of CB2 in airway sensory nerve function.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301,H315,H319,H335,H413

Classificações de perigo

Acute Tox. 3 Oral - Aquatic Chronic 4 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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