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J4455

Sigma-Aldrich

JSH-23

≥98% (HPLC), solid

Sinônimo(s):

4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

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About This Item

Fórmula empírica (Notação de Hill):
C16H20N2
Número CAS:
749886-87-1
Peso molecular:
240.34
Código UNSPSC:
51111800
NACRES:
NA.77

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

solid

condição de armazenamento

protect from light

cor

off-white to gray-pink

solubilidade

DMSO: >10 mg/mL

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

InChI

1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3

chave InChI

YMFNPBSZFWXMAD-UHFFFAOYSA-N

Aplicação

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Ações bioquímicas/fisiológicas

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Outras notas

Light and air sensitive.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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SN50 trifluoroacetate salt ≥95% (HPLC)

Sigma-Aldrich

SML1471

SN50 trifluoroacetate salt

Sodium 4-aminosalicylate dihydrate ≥97.0% (T)

Sigma-Aldrich

09415

Sodium 4-aminosalicylate dihydrate

Ammonium pyrrolidinedithiocarbamate ~99%

Sigma-Aldrich

P8765

Ammonium pyrrolidinedithiocarbamate

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L Shi et al.
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The coordination between cellular differentiation and the mesenchymal/stem transition is essential for both embryo development and neoplasia, suggesting a mechanistic link between these two major processes. In this work we show that miR-127, an embryo-expressing lung miRNA, was prominently induced
Xia Kang et al.
Clinical science (London, England : 1979), 130(14), 1257-1268 (2016-04-30)
Transcription factor 4 (TCF-4) was recently identified as a candidate gene for the cause of type 2 diabetes, although the mechanisms have not been fully elucidated. In the present study, we demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet
Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice.
Kang X et al.
Clinical Science (London, England : 1979), 130, 1257-1257 (2016)
Xiaoyu Cheng et al.
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Serum uric acid is reportedly associated with thrombosis development. However, still unclear is the mechanism of high uric acid in thrombosis with the involvement of let-7c. In an aim to fill this void, we conducted this study by treating mice
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