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B5556

Sigma-Aldrich

Bay 11-7082

≥98% (HPLC), powder, NF-kB/TNF-α inhibitor

Sinônimo(s):

(E)-3-(4-Methylphenylsulfonyl)-2-propenenitrile

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About This Item

Fórmula empírica (Notação de Hill):
C10H9NO2S
Número CAS:
19542-67-7
Peso molecular:
207.25
Número MDL:
MFCD00712162
Código UNSPSC:
12352200
ID de substância PubChem:
24891842
NACRES:
NA.77

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Nome do produto

Bay 11-7082, ≥98% (HPLC), powder

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white

solubilidade

DMSO: >20 mg/mL
H2O: insoluble

cadeia de caracteres SMILES

Cc1ccc(cc1)S(=O)(=O)\C=C\C#N

InChI

1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+

chave InChI

DOEWDSDBFRHVAP-KRXBUXKQSA-N

Aplicação

Bay 11-7082 has been used as:
  • a nuclear factor-kappa B (NF-kB) inhibitor to verify the action of the NF-kB signaling pathway in the production of interleukin (IL)-8[1]
  • a nuclear factor-kappa B (NF-kB) inhibitor to study the role of NF-kB activation in Mycoplasma hyorhinis -induced epithelial-mesenchymal transition (EMT) and cell migration[2]
  • a nod-like receptor family pyrin domain containing 3 (NLRP3) selective inhibitor to examine its effects on liver inflammation in mice after hematopoietic stem cell transplantation[3]

Ações bioquímicas/fisiológicas

Bay 11-7082 acts as a selective inhibitor for nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome pathway.[4] In addition, to the inhibition of nuclear factor-kappa B (NF-kB), Bay 11-7082 also triggers apoptosis in anucleated erythrocytes[5], human T-cell leukemia virus type I (HTLV-I)-infected T-cell lines and primary adult T-cell leukemia cells.[6]
Bay 11-7082 is an inhibitor of cytokine-induced IκB-α phosphorylation.

Características e benefícios

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
0000164591
065M4616V
063M4620V
121M4613V
090M46231V

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NF-κB Activation Inhibitor II, JSH-23 The NF-κB Activation Inhibitor II, JSH-23, also referenced under CAS 749886-87-1, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

Millipore

481408-M

NF-κB Activation Inhibitor II, JSH-23

INF39 ≥98% (HPLC)

Sigma-Aldrich

SML2239

INF39

LY-294,002 hydrochloride solid, ≥98% (HPLC)

Sigma-Aldrich

L9908

LY-294,002 hydrochloride

Guoping Cheng et al.
OncoTargets and therapy, 9, 7563-7571 (2016-12-23)
α-Catenin is an important molecule involved in the maintenance of cell-cell adhesion and a prognostic marker in cancer since its expression is essential for preventing cancer metastasis. However, the mechanism that leads to the downregulation of α-catenin in cancer progression
Busulfan and cyclosphamide induce liver inflammation through NLRP3 activation in mice after hematopoietic stem cell transplantation
Qiao J, et al.
Scientific reports, 5, 17828-17828 (2015)
P Luz-Crawford et al.
Annals of the rheumatic diseases, 75(12), 2166-2174 (2016-03-11)
To define how peroxisome proliferator-activated receptor (PPAR) β/δ expression level in mesenchymal stem cells (MSCs) could predict and direct both their immunosuppressive and therapeutic properties. PPARβ/δ interacts with factors such as nuclear factor-kappa B (NF-κB) and regulates the expression of
The NFkB pathway inhibitors Bay 11-7082 and parthenolide induce programmed cell death in anucleated Erythrocytes
Ghashghaeinia, et al.
Cellular Physiology and Biochemistry, 27(1), 45-54 (2011)
Rawan El-Amine et al.
Redox biology, 15, 97-108 (2017-12-09)
Human immunodeficiency virus (HIV) infection is associated with B-cell malignancies in patients though HIV-1 is not able to infect B-cells. The rate of B-cell lymphomas in HIV-infected individuals remains high even under the combined antiretroviral therapy (cART) that reconstitutes the
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