H8666
Transforming Growth Factor-β2 human
≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture
Sinônimo(s):
TGF-β2
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5 μG
R$ 2.636,00
About This Item
R$ 2.636,00
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Nome do produto
Transforming Growth Factor-β2 human, TGF-β2, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
fonte biológica
human
Nível de qualidade
recombinante
expressed in HEK 293 cells
Ensaio
≥95% (SDS-PAGE)
Formulário
lyophilized powder
potência
≤0.5 ng/mL EC50
qualidade
endotoxin tested
peso molecular
dimer 25 kDa (non-glycosylated)
embalagem
pkg of 5 μg
condição de armazenamento
avoid repeated freeze/thaw cycles
técnica(s)
cell culture | mammalian: suitable
Impurezas
≤1 EU/μg
nº de adesão UniProt
temperatura de armazenamento
−20°C
Informações sobre genes
human ... TGFB2(7042)
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Descrição geral
Transforming growth factor-β2 (TGF-β2) belongs to the TGF-β superfamily.[1] All threes isoforms (TGF-β1, TGF-β2 and TGF-β3) are known to share similar structure and function.[2] The TGFB2 gene is mapped to human chromosome 1q41 and is localized to extracellular matrix.[3][4] The active form of TGF-β precursor is produced upon proteolytic cleavage. TGF-β1 and TGF-β2 have 70% amino acid sequence identity.[4]
Ações bioquímicas/fisiológicas
TGF-β2 is important for immune homeostasis by balancing lymphocyte proliferation, apoptosis, hematopoiesis, and embryogenesis. TGF-β2 is crucial in cell growth, differentiation, and survival.[5] TGF-β2 is a strong growth inhibitor for normal and transformed epithelial, lymphoid, fibroblast, and keratinocyte cells.[6] TGF-β is associated with the process of tumor development, progression and metastasis.[7] TGF-β2 is a tumor suppressor in the early stages of carcinogenesis, but in the later stages acts as a tumor promoter by inducing epithelial-mesenchymal transition and stimulating angiogenesis.[5] TGF-β2 inhibits antitumor action of NK (natural killer) cells, T-cells, macrophages, monocytes and neutrophils.[7] TGF-β is also associated with inflammation and wound healing.[8] The TGF-β gene is overexpressed in glioma tumors and also in colon cancer, gastric cancer and cervical lesions.[2]
Transforming growth factor-β2 (TGF-β2), like TGF-β1, is produced by many cell types and reported to be most concentrated in mammalian platelets.
Nota de preparo
HumanKine TGF-β2 is expressed in human HEK 293 cells as a mature, non-glycosylated, disulfide-linked homodimer with a predicted molecular mass of approx. 25 kDa.
Nota de análise
The specific activity was determined by the dose-dependent inhibition of IL-4 induced proliferation of mouse HT-2 (BALB/c spleen activated by sheep erythrocytes in the presence of IL-2).
Informações legais
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
produto comparável
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Sunder Sims-Lucas et al.
Differentiation; research in biological diversity, 79(4-5), 272-284 (2010-02-19)
Many members of the transforming growth factor-beta (TGF-beta) superfamily have been shown to be important regulators of metanephric development. In this study, we characterized the effect of TGF-beta2 on metanephric development. Rat and mouse metanephroi cultured in the presence of
Loss-of-function mutations in TGFB2 cause a syndromic presentation of thoracic aortic aneurysm
Lindsay ME, et al.
Nature Genetics, 44(8), 922?927-922?927 (2012)
Evaluation of zinc finger E-box binding homeobox 1 and transforming growth factor-β2 expression in bladder cancer tissue in comparison with healthy adjacent tissue.
Mahdavinezhad A, et al.
Investigative and Clinical Urology, 58(2), 140-145 (2017)
A Signaling Pathway Involving TGF-β2 and Snail in Hair Follicle Morphogenesis
Jamora C, et al.
PLoS Biology, 3.1 (2004)
Carlos I Lorda-Diez et al.
BMC developmental biology, 10, 69-69 (2010-06-23)
Transforming growth factor beta proteins (Tgfbetas) are secreted cytokines with well-defined functions in the differentiation of the musculoskeletal system of the developing limb. Here we have studied in chicken embryos, whether these cytokines are implicated in the development of the
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