G1404
Glutathione reduced ethyl ester
≥90% (TLC)
Sinônimo(s):
γ-Glu-Cys-Gly-OEt, GSH-MEE
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About This Item
Fórmula empírica (Notação de Hill):
C12H21N3O6S
Número CAS:
Peso molecular:
335.38
Número MDL:
Código UNSPSC:
12161504
ID de substância PubChem:
NACRES:
NA.26
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Nome do produto
Glutathione reduced ethyl ester, ≥90% (TLC)
Nível de qualidade
Ensaio
≥90% (TLC)
Formulário
powder
cor
white to off-white
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
CCOC(=O)CNC(=O)[C@H](CS)NC(=O)CC[C@H](N)C(O)=O
InChI
1S/C12H21N3O6S/c1-2-21-10(17)5-14-11(18)8(6-22)15-9(16)4-3-7(13)12(19)20/h7-8,22H,2-6,13H2,1H3,(H,14,18)(H,15,16)(H,19,20)/t7-,8-/m0/s1
chave InChI
JKRODHBGNBKZLE-YUMQZZPRSA-N
Amino Acid Sequence
Glu-Cys-Gly-OEt
Aplicação
Glutathione reduced ethyl ester has been used:
- to increase intracellular glutathione levels in mouse fibroblast L929 cells
- as a medium supplement in Spodoptera frugiperda (Sf)9 cells
- to evaluate its effect on lipid peroxidation after spinal cord injury
Ações bioquímicas/fisiológicas
Glutathione reduced ethyl ester (GSH-MEE) is a membrane/lipid permeable derivative of GSH that may be used to partially supplement the GSH supply within cells subjected to cysteine and/or GSH depletion. GSH-MEE is hydrolysed by intracellular esterases to release GSH, thereby increases the concentrations of intracellular GSH. It prevents the toxic effects of acetaminophen in animal cells. It protects human lymphoid cells and skin fibroblasts against the damage caused due to radiation.
Glutathione reduced ethyl ester inhibits melanin synthesis by inhibiting tyrosinase activity in Melan-A cells. Its antimelanogenic functionality has potential in treating hyperpigmentation skin disorders. GEE supplementation during islets isolation form pancreas reduces reactive oxygen species production and apoptosis.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Glutathione ethyl ester supplementation during pancreatic islet isolation improves viability and transplant outcomes in a murine marginal islet mass model
do Amaral ASR, et al.
Testing, 8(2), e55288-e55288 (2013)
Modulation of endothelial GSH concentrations: effect of exogenous GSH and GSH monoethyl ester.
Tsan MF
Journal of Applied Physiology, 66(3), 1029-1034 (1989)
M E Anderson et al.
Archives of biochemistry and biophysics, 239(2), 538-548 (1985-06-01)
Glutathione monoethyl ester (L-gamma-glutamyl-L-cysteinylglycyl ethyl ester), in contrast to glutathione itself, is effectively transported into many types of cells. The ester is converted intracellularly into glutathione. Intraperitoneal injection of 35S-labeled ester into mice was followed by rapid appearance of isotope
Targeted supplementation design for improved production and quality of enveloped viral particles in insect cell-baculovirus expression system
Monteiro F, et al.
Journal of Biotechnology, 233(2), 34-41 (2016)
Anja Kahl et al.
Stroke, 49(5), 1223-1231 (2018-04-13)
Ischemic brain injury is characterized by 2 temporally distinct but interrelated phases: ischemia (primary energy failure) and reperfusion (secondary energy failure). Loss of cerebral blood flow leads to decreased oxygen levels and energy crisis in the ischemic area, initiating a
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