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Key Documents

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G0267

Sigma-Aldrich

Mini Gastrin I human

≥97% (HPLC)

Sinônimo(s):

HG-13

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About This Item

Fórmula empírica (Notação de Hill):
C74H99N15O26S
Número CAS:
60748-07-4
Peso molecular:
1646.73
Número MDL:
MFCD00133359
Código UNSPSC:
12352200

Ensaio

≥97% (HPLC)

nº de adesão UniProt

P01350

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc4ccccc4)C(N)=O

Informações sobre genes

human ... GAST(2520)

Amino Acid Sequence

Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH2

Ações bioquímicas/fisiológicas

CCKB/gastrin receptor agonist. Corresponds to fragment 5-17 of human gastrin I. This form of gastrin has been isolated from tumor tissue.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Johanna Dalmo et al.
Oncology reports, 27(1), 174-181 (2011-10-14)
To be able to evaluate new radiopharmaceuticals and optimize diagnostic and therapeutic procedures, relevant animal models are required. The aim of this study was to evaluate the medullary thyroid carcinoma GOT2 animal model by analyzing the biodistribution of 177Lu-octreotate and
Stephan Good et al.
European journal of nuclear medicine and molecular imaging, 35(10), 1868-1877 (2008-05-30)
Diethylenetriamine-pentaacetic acid (DTPA)-coupled minigastrins are unsuitable for therapeutic application with the available beta-emitting radiometals due to low complex stability. Low tumour-to-kidney ratio of the known radiopharmaceuticals is further limiting their potency. We used macrocyclic chelators for coupling to increase complex
Elisabeth Laabs et al.
Investigative radiology, 46(3), 196-201 (2010-12-09)
A variety of tumors in different organs with good accessibility to near-infrared light express the cholecystokinin-2 (CCK₂)/gastrin receptor. Therefore, the applicability of fluorescence optical imaging was assessed using a novel peptide probe. This study was approved by the regional animal
Anna Lucia Tornesello et al.
Journal of peptide science : an official publication of the European Peptide Society, 17(5), 405-412 (2011-02-26)
The development of suitable radioligands for targeting CCK-2 receptor expressing tumors, such as medullary thyroid carcinoma, is of great clinical interest. In the search for the best CCK-2R binding peptides, we have synthesized, evaluated and compared the CCK8 peptide (Asp-Tyr-Met-Gly-Trp-Met-Asp-PheNH(2)
Elisabeth von Guggenberg et al.
Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 14(3), 366-375 (2011-07-07)
Targeting of cholecystokinin receptor expressing malignancies such as medullary thyroid carcinoma is currently limited by low in vivo stability of radioligands. To increase the stability, we have developed and preclinically evaluated two cyclic 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-minigastrin analogs radiolabeled with (111)In
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