If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf
FD4
Isotiocianato de fluoresceína–dextrana
average mol wt 3,000-5,000
Sinônimo(s):
FITC–Dextrana
Selecione um tamanho
| Tamanho/SKU | Disponibilidade | Preço |
|---|---|---|
100 mg | Verificar disponibilidade no carrinho | R$ 966,00 |
250 mg | Verificar disponibilidade no carrinho | R$ 1.590,00 |
1 g | Verificar disponibilidade no carrinho | R$ 4.666,00 |
Sobre este item
biological source
synthetic
Quality Segment
conjugate
FITC conjugate
form
powder
mol wt
average mol wt 3,000-5,000
extent of labeling
0.001-0.020 mol FITC per mol glucose
technique(s)
HPLC: suitable
color
light yellow to dark orange
solubility
H2O: 25 mg/mL
suitability
suitable for HPLC, suitable for fluorescence indicator, suitable for fluorescent labeling techniques
application(s)
life science and biopharma
metabolomics
microbiology
pharmaceutical
storage temp.
2-8°C
General description
Em investigações bioquímicas com foco na barreira hematoencefálica (BHE), a FITC-Dextrana, particularmente a variante com um peso molecular médio de 4000, tem um papel central. Ela serve como uma ferramenta confiável para avaliar a permeabilidade de solutos, íons e proteínas em toda a BHE, promovendo uma compreensão melhor da integridade da barreira e de quaisquer possíveis interrupções. Essa contribuição para a exploração bioquímica é inestimável para esclarecer os mecanismos de defesa do cérebro.
Além disso, a FITC-Dextrana desempenha um papel fundamental em estudos relacionados à permeabilidade celular na área de pesquisa bioquímica. Isso se estende à avaliação da permeabilidade da BHE e à extensão das rupturas dentro da BHE, aspectos que são fundamentais para a pesquisa de neurociência e fornecimento de medicamentos. Essas facetas da pesquisa bioquímica são essenciais para compreender os mecanismos da doença e formular estratégias terapêuticas eficazes.
Além disso, a FITC-Dextrana é um marco nos estudos cardiovasculares, de microcirculação e de perfusão. Ela funciona como um composto traçador de fluxo fluorescente, permitindo a medição de processos críticos, como fluxo sanguíneo, integridade da membrana, drenagem vascular e eliminação renal. Em suma, a FITC-Dextrana prova ser um ativo indispensável nos campos da biologia, bioquímica e medicina, oferecendo percepções inigualáveis sobre as complexidades da permeabilidade celular e tecidual, a integridade da barreira hematoencefálica e a compreensão de diversos processos fisiológicos e patológicos.
Application
Biochem/physiol Actions
Features and Benefits
- Adequado para pesquisa bioquímica e biomédica
- Versátil e adaptável a uma ampla variedade de aplicações laboratoriais e de pesquisa
Preparation Note
Other Notes
1 of 1
Este Item | |||
|---|---|---|---|
| description average mol wt 3,000-5,000 | description average mol wt 150,000 | description average mol wt 500,000 | description average mol wt 40,000 |
| biological source synthetic | biological source synthetic | biological source synthetic (organic) | biological source synthetic (organic) |
| technique(s) HPLC: suitable | technique(s) - | technique(s) - | technique(s) - |
| solubility H2O: 25 mg/mL | solubility H2O: 25 mg/mL, clear to slightly hazy, yellow-orange | solubility H2O: soluble 25 mg/mL, clear to slightly hazy, yellow to deep orange | solubility H2O: soluble 25 mg/mL, clear to slightly hazy, yellow to deep orange |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| suitability suitable for HPLC, suitable for fluorescence indicator, suitable for fluorescent labeling techniques | suitability - | suitability - | suitability - |
| form powder | form powder | form powder | form powder |
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Classe de armazenamento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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How can I determine the shelf life / expiration / retest date of this product?
1 answer-
Helpful?
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Hello, I have FITC dextran (FD4 - 100 mg) with a stock concentration of 25 mg/ml. What is the final concentration for a permeability assay (endothelial cells and podocytes in co-culture)?
1 answer-
There isn't one specific final concentration to be used for such an application. It is advised to refer to scientific literature for more details on experimental setup. Below is a citation of an article that could be of potential interest.
't Hart DC, Yildiz D, Palacio-Castañeda V, Li L, Gumuscu B, Brock R, Verdurmen WPR, van der Vlag J, Nijenhuis T. Co-Culture of Glomerular Endothelial Cells and Podocytes in a Custom-Designed Glomerulus-on-a-Chip Model Improves the Filtration Barrier Integrity and Affects the Glomerular Cell Phenotype. Biosensors (Basel). 2023 Mar 3;13(3):339. doi: 10.3390/bios13030339. PMID: 36979551; PMCID: PMC10046631.
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How is shipping temperature determined? And how is it related to the product storage temperature?
1 answer-
Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
Helpful?
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What is the difference between FD4 and 46944?
1 answer-
Products FD4 and 46944 are essentially the same product, but they are offered for sale by different divisions. The primary difference between the two lies in the amount of FITC conjugated to the dextran (glucose). For FD4, the amount of FITC ranges from 0.001 to 0.020, while for 46944, the range is 0.002 to 0.020. It is important to note that individual lots must fall within these specified minimum and maximum values.
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