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68059

Sigma-Aldrich

FITC-CM-Dextran

average mol wt 4,000

Sinônimo(s):

FITC-CM-Dextran 4, Fluorescein isothiocyanate–Carboxymethyl–Dextran, Fluorescein isothiocyanate–Carboxymethyl–Dextran

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1 G
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About This Item

Código UNSPSC:
12352116
NACRES:
NA.32

R$ 3.995,00

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fonte biológica

synthetic

conjugado

FITC conjugate

Formulário

powder or crystals

peso molecular

average mol wt 4,000

composição

carboxymethyl content, 3-7%

Extensão da rotulagem

0.001-0.020 mol/mol FITC glucose

técnica(s)

permeability assay: suitable

fluorescência

λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0

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Descrição geral

FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform. FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.

Aplicação

FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge. [1] It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS.[2] FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
BCCM3761
BCCL2895
BCCK6677
BCCH4911
BCCG7370

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Yuxin Leng et al.
PloS one, 9(10), e109350-e109350 (2014-10-09)
Intra-abdominal hypertension (IAH) is known as a common, serious complication in critically ill patients. Bacterial translocation and permeability changes are considered the pathophysiological bases for IAH-induced enterogenic endotoxemia and subsequent multiorgan failure. Nevertheless, the effects of slightly elevated intra-abdominal pressures
Stefanie J Anderson et al.
Comparative medicine, 69(1), 4-15 (2018-12-14)
Here we characterized the murine dextran sulfate sodium (DSS) model of acute colitis. Specifically, we evaluated azithromycin and metronidazole treatment regimens to assess their effects on animal wellbeing, pathologic changes, barrier function, cytokine and chemokine profiles, and neutrophil migration in
Yuxin Leng et al.
Scientific reports, 6, 22814-22814 (2016-03-17)
Intra-abdominal hypertension (IAH) is a common and serious complication in critically ill patients for which there is no well-defined treatment strategy. Here, we explored the effect of IAH on multiple intestinal barriers and discussed whether the alteration in microflora provides
Chloe Martin et al.
International journal of pharmaceutics, 511(1), 570-578 (2016-07-28)
The need to develop a greater understanding of drug delivery systems has arisen through the development of alternative biological based therapeutics. Drug delivery systems need to adapt and respond to this increasing demand for cellular transportation of highly charged species.
Carrier and dose effects on the pharmacokinetics of T-0128, a camptothecin analogue-carboxymethyl dextran conjugate, in non-tumor- and tumor-bearing rats.
Harada M, Murata J, Sakamura Y, et al.
J. Controlled Release, 71, 71-86 (2001)
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