C4042

Captopril

≥98% (HPLC), powder, angiotensin converting enzyme inhibitor

• Sinônimo(s): N-[(S)-3-Mercapto-2-methylpropionyl]-L-proline
• Fórmula empírica (Notação de Hill): C₉H₁₅NO₃S
• Número CAS: 62571-86-2
• Peso molecular: 217.29
• Beilstein: 477887
• Número CE: 263-607-1
• Número MDL: MFCD00168073
• Código UNSPSC: 12352200
• ID de substância PubChem: 57654003
• NACRES: NA.77

Propriedades

• Nome do produto: Captopril, ≥98% (HPLC), powder
• fonte biológica: synthetic
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to off-white
• pf: 104-108 °C (lit.)
• solubilidade: water: 100 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• originador: Bristol-Myers Squibb
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O
• InChI: 1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1
• chave InChI: FAKRSMQSSFJEIM-RQJHMYQMSA-N
• Informações sobre genes: human ... ACE(1636) , AGTR1(185) , AGTR2(186) , ECE1(1889) ; rat ... Ace(24310)

Descrição

Aplicação

Captopril has been used:

• to examine the influence of timing of captopril treatment on efficacy in transverse aortic constriction (TAC) mice[1]
• as an angiotensin-converting enzyme inhibitor and orally administered to unrestrained Wistar Kyoto rats in an approach to study its effects of angiogenesis inhibition and interdependency with other drugs[2]
• used as a positive control in spectrophotometric assay to study the angiotensin-converting enzyme inhibitory activity[3]

Ações bioquímicas/fisiológicas

Angiotensin converting enzyme inhibitor. Inhibits the formation of angiotensin II, a bioactive peptide that stimulates angiogenesis and increases microvessel density.

Captopril is known to decrease the cardiovascular complications arising due to myocardial infarction.[4] It is an effective drug in treating diabetic nephropathy and renal disease.[5] Captopril acts by reducing cardiac related inflammation, fibrosis and calcification.[6]

Características e benefícios

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Bristol-Myers Squibb. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS08
• Palavra indicadora: Danger
• Frases de perigo: H341,H360F
• Declarações de precaução: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Classificações de perigo: Muta. 2 - Repr. 1B
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges