T6031

DL-Thiorphan

≥98% (TLC)

• Sinônimo(s): (±)-N-(3-Mercapto-2-benzylpropionyl)glycine, DL-3-Mercapto-2-benzylpropanoylglycine
• Fórmula empírica (Notação de Hill): C₁₂H₁₅NO₃S
• Número CAS: 76721-89-6
• Peso molecular: 253.32
• Beilstein: 4872101
• Número MDL: MFCD00058435
• Código UNSPSC: 12352200
• ID de substância PubChem: 24278747
• NACRES: NA.77

Propriedades

• Nível de qualidade: 200
• Ensaio: ≥98% (TLC)
• forma: powder
• pf: 138 °C
• solubilidade: ethanol: soluble 49.00-51.00 mg/mL, clear, colorless
• cadeia de caracteres SMILES: OC(=O)CNC(=O)C(CS)Cc1ccccc1
• InChI: 1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)
• chave InChI: LJJKNPQAGWVLDQ-UHFFFAOYSA-N
• Informações sobre genes: human ... ACE(1636) , ECE1(1889) ; rat ... Ace(24310) , Mme(24590)

Descrição

Descrição geral

Thiorphan, also called DL-mercapto-2-benzylpropanoyl-glycine is a specific and potent inhibitor of enkephalinase in nanomolar concentrations. It is an inhibitor of neutral endopeptidase. It interacts with cluster of differentiation 10 (CD10) in bone marrow cells and may modulate hematopoiesis. Thiorphan is a safe drugprescribed for diarrhea. It prevents cortical damage in newborn mice and is a potent agent for treating cerebral palsy.(CP)

Aplicação

DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase. DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.

Ações bioquímicas/fisiológicas

Enkephalinase inhibitor.

Características e benefícios

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparo

DL-Thiorphan is soluble in ethanol at 49.00 - 51.00 mg/ml and yields a clear, colorless solution.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)