C2618

Cytochalasin D

Ready Made Solution, from Zygosporium mansonii, 5 mg/mL in DMSO

• Sinônimo(s): Lygosporin A, Zygosporin A
• Fórmula empírica (Notação de Hill): C₃₀H₃₇NO₆
• Número CAS: 22144-77-0
• Peso molecular: 507.62
• Beilstein: 1632828
• Número MDL: MFCD00077706
• Código UNSPSC: 51102829
• ID de substância PubChem: 329775013
• NACRES: NA.85

Propriedades

• fonte biológica: Zygosporium mansonii
• Nível de qualidade: 300
• forma: solution
• concentração: 5 mg/mL in DMSO
• espectro de atividade do antibiótico: fungi
• Modo de ação: enzyme | interferes
• Condições de expedição: wet ice
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: [H][C@@]12[C@H](C)C(=C)[C@@H](O)[C@@H]3\C=C\C[C@H](C)C(=O)[C@](C)(O)\C=C\[C@@H](OC(C)=O)[C@@]13C(=O)N[C@H]2Cc4ccccc4
• InChI: 1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17-,18+,22-,23-,24+,25-,26+,29+,30+/m0/s1
• chave InChI: SDZRWUKZFQQKKV-JHADDHBZSA-N

Descrição

Aplicação

Cytochalasin D are isomeric metabolites of Metarrhizium anisopliae. Cytochalasin D possesses antibiotic and antitumor activity. It also impairs maintenance of long term potentiation (LTP) of actin filaments. It is implicated in promoting conditions favorable for depolymerizing actin.

Ações bioquímicas/fisiológicas

Cell permeable fungal toxin; potent inhibitor of actin polymerization. Disrupts actin microfilaments and activates the p53-dependent pathways causing arrest of the cell cycle at the G1-S transition. Inhibits smooth muscle contraction. Inhibits insulin-stimulated, but not basal, transport of glucose.

Potent inhibitor of actin polymerization; disrupts actin microfilaments; activates the p53-dependent pathways; inhibits smooth muscle contraction; inhibits insulin-stimulated glucose transport.

Outras notas

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): 188.6 °F - closed cup - Solvent
• Ponto de fulgor (°C): 87 °C - closed cup - Solvent
• Equipamento de proteção individual: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)