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A5922

Sigma-Aldrich

Amifostine trihydrate

≥97% (TLC), powder

Sinônimo(s):

2-(3-Aminopropyl)aminoethyl phosphorothioate, WR2721

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About This Item

Fórmula empírica (Notação de Hill):
C5H15N2O3PS · 3 H2O
Número CAS:
112901-68-5
Peso molecular:
268.27
Número MDL:
MFCD00453866
Código UNSPSC:
12352200
ID de substância PubChem:
24278231
NACRES:
NA.77

Nível de qualidade

200

Ensaio

≥97% (TLC)

forma

powder

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

OP(SCCNCCCN)(O)=O.O.O.O

InChI

1S/C5H15N2O3PS.3H2O/c6-2-1-3-7-4-5-12-11(8,9)10;;;/h7H,1-6H2,(H2,8,9,10);3*1H2

chave InChI

TXQPXJKRNHJWAX-UHFFFAOYSA-N

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Aplicação

Amifostine may provide renal protection during PRRT using somatostatin analogs by mitigating radiation damage and reducing the absorbed kidney radiation dose. Amifostine remediates the degenerative effects of radiation on the mineralization capacity of the murine mandible.

Ações bioquímicas/fisiológicas

Radioprotective agent. Selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. Selectivity is due to preferential uptake by normal tissues and subsequent metabolic activation to 2-(3-aminopropyl)aminoethanethiol.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302

Declarações de precaução

P264 - P270 - P301 + P312 - P501

Classificações de perigo

Acute Tox. 4 Oral

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

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Murat Caloglu et al.
Journal of cancer research and therapeutics, 8(2), 260-265 (2012-07-31)
The aim of the study was to compare the protective efficacy of l-carnitine (LC) to amifostine on radiation-induced acute small intestine damage. Thirty, 4-week-old Wistar albino rats were randomly assigned to four groups - Group 1: control (CONT, n =
Michael I Koukourakis et al.
International journal of radiation oncology, biology, physics, 85(1), e7-13 (2012-10-09)
Postmastectomy radiation therapy (PMRT) provides major local control and survival benefits. More aggressive radiation therapy schemes may, however, be necessary in specific subgroups, provided they are safely administered. We report the tolerance and efficacy of a highly accelerated and hypofractionated
Isabella Russo et al.
Diabetes, 61(11), 2913-2921 (2012-07-28)
Since hyperglycemia is involved in the "aspirin resistance" occurring in diabetes, we aimed at evaluating whether high glucose interferes with the aspirin-induced inhibition of thromboxane synthesis and/or activation of the nitric oxide (NO)/cGMP/cGMP-dependent protein kinase (PKG) pathway in platelets. For
V Vendramini et al.
Human reproduction (Oxford, England), 27(8), 2457-2466 (2012-05-18)
In a previous study, we found that amifostine provides some protection to the seminiferous epithelium of prepubertal doxorubicin-treated male rats but does not improve their fertility status as adults. Based on these results, a long-term study was undertaken to evaluate
Low-dose antioxidant is sufficient to regulate pulmonary redox equilibration.
Kong Zhengdong et al.
Critical care medicine, 40(5), 1693-1694 (2012-04-19)
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