A3230

AR-A014418

≥98% (HPLC), solid

• Sinônimo(s): N-(4-Methoxybenzyl)-N′-(5-nitro-1,3-thiazol-2-yl)urea
• Fórmula empírica (Notação de Hill): C₁₂H₁₂N₄O₄S
• Número CAS: 487021-52-3
• Peso molecular: 308.31
• Número MDL: MFCD08277040
• Código UNSPSC: 12352200
• ID de substância PubChem: 329770820
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: solid
• cor: off-white to tan
• solubilidade: DMSO: ≥20 mg/mL, clear, light yellow; H₂O: insoluble
• originador: AstraZeneca
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: COc1ccc(CNC(=O)Nc2ncc(s2)[N+]([O-])=O)cc1
• InChI: 1S/C12H12N4O4S/c1-20-9-4-2-8(3-5-9)6-13-11(17)15-12-14-7-10(21-12)16(18)19/h2-5,7H,6H2,1H3,(H2,13,14,15,17)
• chave InChI: YAEMHJKFIIIULI-UHFFFAOYSA-N

Descrição

Descrição geral

AR-A014418 may have chronic pain-relieving properties. In mice having neuropathic pain, this molecule has been shown to have antihyperalgesic effects. AR-A014418 may modulate proinflammatory cytokines and the catecholaminergic and serotonergic pathways. It has also been studied that AR-A014418 inhibits growth of pancreatic cancer cells.

Aplicação

AR-A014418 has been used as an inhibitor of glycogen synthase kinase 3 (GSK3).

Ações bioquímicas/fisiológicas

Glycogen synthase kinase 3 (GSK3) is a serine/threonine kinase that has been implicated in pathological conditions such as diabetes and Alzheimer′s disease. GSK3 inhibitor, AR-A014418, inhibits GSK3 (IC₅₀ = 104 nM), in an ATP-competitive manner (Ki = 38 nM). AR-A014418 does not significantly inhibit cdk2 or cdk5 (IC₅₀ > 100 μM) or 26 other kinases, demonstrating high specificity for GSK3.

Características e benefícios

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves