We have not done any such testing, but the following references may be helpful: https://jpet.aspetjournals.org/cgi/content/abstract/320/3/1013, https://molpharm.aspetjournals.org/cgi/reprint/66/1/187.
L9908
LY-294,002 hydrochloride
from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor
Sinônimo(s):
2-(4-Morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride
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1 MG
R$ 749,00
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R$ 2.137,00
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1 MG
R$ 749,00
5 MG
R$ 2.137,00
About This Item
Fórmula empírica (Notação de Hill):
C19H17NO3 · HCl
Número CAS:
Peso molecular:
343.80
Número MDL:
Código UNSPSC:
12352207
ID de substância PubChem:
NACRES:
NA.77
Produtos recomendados
Nome do produto
LY-294,002 hydrochloride, solid, ≥98% (HPLC)
fonte biológica
microbial (Staphylococcus roseus)
Nível de qualidade
Ensaio
≥98% (HPLC)
Formulário
solid
cor
white to off-white
solubilidade
DMSO: >5 mg/mL
H2O: insoluble
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
InChI
1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
chave InChI
CZQHHVNHHHRRDU-UHFFFAOYSA-N
Descrição geral
LY-294,002 hydrochloride is a derivative of the flavonoid, quercetin and elicits higher inhibition on the enzyme phosphoinositide 3-kinase (PI3K).[1] LY-294,002 inhibits nuclear factor kappa B signaling in macrophages.[2] It elevates expression of autophagosomal protein LC3 and promotes apoptosis in gastric[3] and nasopharyngeal cancer cells.[4] LY-294,002 modulates action potential repolarization and improves myocyte contractility.[5]
Aplicação
Ações bioquímicas/fisiológicas
Specific cell permeable phosphatidylinositol 3-kinase inhibitor.
Características e benefícios
This compound is a featured product for Cyclic Nucleotide and Kinase Phosphatase Biology research. Discover more featured Cyclic Nucleotide and Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the G Proteins (Heterotrimeric) and Phosphoinositide Kinases pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Certificados de análise (COA)
Lot/Batch Number
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Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
Walker EH, et al.
Molecular Cell, 6(4), 909-919 (2000)
miR-126 suppresses epithelial-to-mesenchymal transition and metastasis by targeting PI3K/AKT/Snail signaling of lung cancer cells
Jia Z, et al.
Oncology Letters, 15(5), 7369-7375 (2018)
The Phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 modulates cytokine expression in macrophages via p50 nuclear factor kappa B inhibition, in a PI3K-independent mechanism
Avni D, et al.
Biochemical Pharmacology, 83(1), 106-114 (2012)
Endothelial cell activation on 3D-matrices derived from PDGF-BB-stimulated fibroblasts is mediated by Snail1
Herrera A, et al.
Oncogenesis, 7(9), 76-76 (2018)
Phosphatidylinositol 3-kinase inhibitor (LY294002) induces apoptosis of human nasopharyngeal carcinoma in vitro and in vivo
Jiang H, et al.
Journal of Experimental & Clinical Cancer Research, 29(1), 34-34 (2010)
Artigos
We presents an article on Autophagy in Cancer Promotes Therapeutic Resistance
Discover Bioactive Small Molecules for Kinase Phosphatase Biology
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Discover Bioactive Small Molecules for Lipid Signaling Research
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Can I use Product L9908, LY-294,002 hydrochloride, in conjugation with Wortmannin?
1 answer-
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What is the solution stability in DMSO for Product L9908, LY-294,002 hydrochloride?
1 answer-
After reconstitution in DMSO, aliquot and freeze the stock solution at -20 °C. DMSO stock solutions are stable for at least 1 month at -20 °C.
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the recommended concentration for using Product L9908, LY-294,002 hydrochloride?
1 answer-
One can use this product at 50 uM concentration.
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