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A0781

Sigma-Aldrich

Aphidicolin from Nigrospora sphaerica

≥98% (HPLC), powder

Sinônimo(s):

APC

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About This Item

Fórmula empírica (Notação de Hill):
C20H34O4
Número CAS:
38966-21-1
Peso molecular:
338.48
Beilstein:
4689958
Número MDL:
MFCD00083214
Código UNSPSC:
12352200
ID de substância PubChem:
57653817
NACRES:
NA.77

Nível de qualidade

300

Ensaio

≥98% (HPLC)

Formulário

powder

atividade óptica

[α]27/D +12°, c = 1 in methanol(lit.)

cor

white

pf

227-233 °C (lit.)

solubilidade

ethanol: 1 mg/mL (stable at least a week at 4°C.)
DMSO: 10 mg/mL (stable at least six weeks at −20°C.)
methanol: 10 mg/mL
H2O: insoluble

espectro de atividade do antibiótico

neoplastics
viruses

Modo de ação

DNA synthesis | interferes

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[H][C@@]12CC[C@@]3([H])[C@](C)(CO)[C@H](O)CC[C@]3(C)[C@]14CC[C@](O)(CO)[C@]([H])(C2)C4

InChI

1S/C20H34O4/c1-17(11-21)15-4-3-13-9-14-10-19(13,7-8-20(14,24)12-22)18(15,2)6-5-16(17)23/h13-16,21-24H,3-12H2,1-2H3/t13-,14+,15-,16+,17-,18-,19-,20-/m0/s1

chave InChI

NOFOAYPPHIUXJR-APNQCZIXSA-N

Informações sobre genes

human ... POLA1(5422) , POLD1(5424) , POLG(5428)

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Ações bioquímicas/fisiológicas

Aphidicolin is an antibiotic, a potent antiviral and antimitotic agent and DNA polymerase inhibitor.

Características e benefícios

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Atenção

Estimated shelf-life is two years. For optimal stability, it should be protected from light and stored desiccated.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
0000382176
0000382177
0000382176
0000382177
0000340707

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Masao Takeuchi et al.
PloS one, 10(5), e0126562-e0126562 (2015-05-16)
Comprehensive analysis of alterations in gene expression along with neoplastic transformation in human cells provides valuable information about the molecular mechanisms underlying transformation. To further address these questions, we performed whole transcriptome analysis to the human mesenchymal stem cell line
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PLoS pathogens, 11(8), e1005072-e1005072 (2015-08-22)
Mucosa-associated invariant T (MAIT) cells represent a large innate-like evolutionarily conserved antimicrobial T-cell subset in humans. MAIT cells recognize microbial riboflavin metabolites from a range of microbes presented by MR1 molecules. MAIT cells are impaired in several chronic diseases including
Devin Sok et al.
Proceedings of the National Academy of Sciences of the United States of America, 111(49), 17624-17629 (2014-11-26)
Broadly neutralizing antibodies (bnAbs) targeting the trimer apex of HIV envelope are favored candidates for vaccine design and immunotherapy because of their great neutralization breadth and potency. However, methods of isolating bnAbs against this site have been limited by the
Athan C Baillet et al.
Arthritis & rheumatology (Hoboken, N.J.), 67(6), 1535-1547 (2015-01-28)
Chlamydia trachomatis is a sexually transmitted obligate intracellular pathogen that causes inflammatory reactive arthritis, spondylitis, psoriasiform dermatitis, and conjunctivitis in some individuals after genital infection. The immunologic basis for this inflammatory response in susceptible hosts is poorly understood. As ZAP-70(W163C)
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Nature communications, 6, 6833-6833 (2015-05-15)
The avian origin A/H7N9 influenza virus causes high admission rates (>99%) and mortality (>30%), with ultimately favourable outcomes ranging from rapid recovery to prolonged hospitalization. Using a multicolour assay for monitoring adaptive and innate immunity, here we dissect the kinetic
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