This product is soluble in DMSO (10 mg/mL). At higher concentrations, heating is required for the product to dissolve completely (approximately 10 minutes at 95°C), but some precipitation occurs upon cooling to room temperature. It is also soluble in 1 N NaOH (50 mg/mL) and methanol (50 mg/mL).
C9911
(S)-(+)-Camptothecin
≥90% (HPLC), powder, DNA topoisomerase I inhibitor
Sinônimo(s):
(S)-4-Ethyl-4-hydroxy-1H-pyrano-[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
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100 MG
R$ 1.158,00
250 MG
R$ 2.534,00
1 G
R$ 6.933,00
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100 MG
R$ 1.158,00
250 MG
R$ 2.534,00
1 G
R$ 6.933,00
About This Item
Fórmula empírica (Notação de Hill):
C20H16N2O4
Número CAS:
Peso molecular:
348.35
Beilstein:
631069
Número MDL:
Código UNSPSC:
12352200
ID de substância PubChem:
NACRES:
NA.77
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Nome do produto
(S)-(+)-Camptothecin, ≥90% (HPLC), powder
Nível de qualidade
Ensaio
≥90% (HPLC)
Formulário
powder
pf
260 °C (dec.) (lit.)
solubilidade
chloroform/methanol (4:1): 5 mg/mL
espectro de atividade do antibiótico
neoplastics
Modo de ação
DNA synthesis | interferes
enzyme | inhibits
temperatura de armazenamento
2-8°C
cadeia de caracteres SMILES
CC[C@@]1(O)C(=O)OCC2=C1C=C3N(Cc4cc5ccccc5nc34)C2=O
InChI
1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
chave InChI
VSJKWCGYPAHWDS-FQEVSTJZSA-N
Informações sobre genes
human ... TOP1(7150)
mouse ... Prkca(18750)
rat ... Sstr2(54305)
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Ações bioquímicas/fisiológicas
(S)-(+)-Camptothecin binds irreversibly to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. The enzyme complex is ubiquinated and destroyed by the 26S proteasome, thus depleting cellular topoisomerase I. Blocks the cell cycle in S-phase at low does and induces apoptosis in a large number of normal and tumor cell lines by cell cycle-dependent and cell cycle-independent processes.
Características e benefícios
This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Outras notas
20S isomer
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Acute Tox. 3 Oral - Muta. 1B
Código de classe de armazenamento
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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What is Product C9911, (S)-(+)-Camptothecin, soluble in?
1 answer-
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the extinction coefficient of Product C9911, (S)-(+)-Camptothecin?
1 answer-
The millimolar extinction coefficients (EmM) at various wavelengths are 37.3 (220 nm); 29.2 (254 nm); 4.9 (290 nm); 19.9 (370 nm).
Helpful?
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What is the solution stability of Product C9911, (S)-(+)-Camptothecin?
1 answer-
Stock solutions of camptothecin in DMSO can be stored at -20°C for up to 3 months.
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