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94646

Sigma-Aldrich

Poli(etilenoglicol)

BioUltra, 35,000

Sinônimo(s):

PEG

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About This Item

Fórmula linear:
H(OCH2CH2)nOH
Número CAS:
25322-68-3
Número MDL:
MFCD00081839
Código UNSPSC:
12352104
ID de substância PubChem:
24890034
NACRES:
NA.26

linha de produto

BioUltra

forma

powder or crystals (or flakes)

peso molecular

Mr ~35000

Impurezas

insoluble matter:, passes filter test
≤0.005% peroxides (as H2O2):

pH

5.5-7.0 (25 °C, 50 mg/mL in H2O)

pf

64-66 °C

solubilidade

H2O: 50 mg/mL at 25 °C, clear, colorless

traços de ânion

chloride (Cl-): ≤50 mg/kg
sulfate (SO42-): ≤50 mg/kg

traços de cátion

Al: ≤5 mg/kg
As: ≤0.1 mg/kg
Ba: ≤5 mg/kg
Bi: ≤5 mg/kg
Ca: ≤10 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cr: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
K: ≤200 mg/kg
Li: ≤5 mg/kg
Mg: ≤5 mg/kg
Mn: ≤5 mg/kg
Mo: ≤5 mg/kg
Na: ≤200 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Sr: ≤5 mg/kg
Zn: ≤5 mg/kg

λ

50 mg/mL in H2O

Absorção UV

λ: 260 nm Amax: 0.12
λ: 280 nm Amax: 0.12

cadeia de caracteres SMILES

C(CO)O

InChI

1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2

chave InChI

LYCAIKOWRPUZTN-UHFFFAOYSA-N

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Descrição geral

Polyethylene glycol (PEG) is a polyether compound that is used as an additive in cosmetics, pharmaceuticals, and food. It consists of repeated ethylene glycol units[-(CH2CH2O)n].

Aplicação

Poly(ethylene glycol) has been used:
  • as a component of University of Wisconsin (UW) cold preservation solutions to stabilize the cell membrane of hepatocytes during temperature changes
  • as a component of the supercooling solution to study supercooling preservation technique of the rat liver for transplantation and to protect against hypothermic injury
  • to prepare aqueous phase for the fabrication of multicellular spheroid (MCS) cultures

Ações bioquímicas/fisiológicas

Polyethylene glycol (PEG) is a synthetic polymer that is used as a gold standard in bioconjugation and nanomedicine to extend blood circulation time and enhance drug efficacy. It acts as an ice-modulator by preventing ice crystallization, which is beneficial for cellular membranes. PEG provides protection against hypothermic injury, like lipid peroxidation and cell membrane injury. PEG-conjugated drugs are considered safe for use in humans and are approved by the U.S. Food and Drug Administration (FDA). PEG has several biomedical applications, including biosensing, imaging, and tissue engineering. It also repels protein adsorption and lowers the liver uptake, which helps in coating nanoparticles.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Poli(etilenoglicol) analytical standard, for GPC, 20,000

Supelco

81298

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Poli(etilenoglicol) average mol wt 10,000

Sigma-Aldrich

P6667

Poli(etilenoglicol)

Wontae Lee et al.
Nature communications, 10(1), 144-144 (2019-01-13)
Understanding how forces orchestrate tissue formation requires technologies to map internal tissue stress at cellular length scales. Here, we develop ultrasoft mechanosensors that visibly deform under less than 10 Pascals of cell-generated stress. By incorporating these mechanosensors into multicellular spheroids
Bote G Bruinsma et al.
Nature protocols, 10(3), 484-494 (2015-02-19)
The current standard for liver preservation involves cooling of the organ on ice (0-4 °C). Although it is successful for shorter durations, this method of preservation does not allow long-term storage of the liver. The gradual loss of hepatic viability
Thai Thanh Hoang Thi et al.
Polymers, 12(2) (2020-02-07)
Poly(ethylene glycol) (PEG) is widely used as a gold standard in bioconjugation and nanomedicine to prolong blood circulation time and improve drug efficacy. The conjugation of PEG to proteins, peptides, oligonucleotides (DNA, small interfering RNA (siRNA), microRNA (miRNA)) and nanoparticles
Anisha A D'souza et al.
Expert opinion on drug delivery, 13(9), 1257-1275 (2016-04-28)
Polyethylene glycol (PEG) is a polymer of choice in drug delivery systems. This USFDA-approved polymer is popular due to its tunable properties and well-established safety profile: prime requisites considered during the selection of any excipient in formulation development. The unique
Janina-Miriam Noy et al.
Biomacromolecules, 21(6), 2320-2333 (2020-04-29)
Phosphorylcholine is known to repel the absorption of proteins onto surfaces, which can prevent the formation of a protein corona on the surface of nanoparticles. This can influence the fate of nanoparticles used for drug delivery. This material could therefore
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