260M-1

Glycophorin A (GA-R2) Mouse Monoclonal Antibody

• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• Nível de qualidade: 100; 500
• conjugado: unconjugated
• forma do anticorpo: culture supernatant
• tipo de produto de anticorpo: primary antibodies
• clone: GA-R2, monoclonal
• descrição: For In Vitro Diagnostic Use in Select Regions (See Chart)
• forma: buffered aqueous solution
• reatividade de espécies: human
• embalagem: vial of 0.1 mL concentrate (260M-14); vial of 0.5 mL concentrate (260M-15); bottle of 1.0 mL predilute (260M-17); vial of 1.0 mL concentrate (260M-16); bottle of 7.0 mL predilute (260M-18)
• fabricante/nome comercial: Cell Marque^™
• técnica(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500
• Isotipo: IgG2bκ
• controle: bone marrow
• Condições de expedição: wet ice
• temperatura de armazenamento: 2-8°C
• visualização: membranous
• Informações sobre genes: human ... GYPA(2993)

Descrição

Descrição geral

Glycophorins A (GPA) and B (GPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and SU blood groups. Glycophorins span the membrane and present their amino-terminal end to the extracellular surface of the human erythrocyte. The genetic array of expressed glycophorin surface antigens on erythrocytes defines the blood group phenotype of the individual. GPA is the carrier of blood group M and N specificities, while GPB accounts for S and U specificities. GPA and GPB provide the cells with a large mucin-like surface and it has been suggested this provides a barrier to cell fusion thus minimizing aggregation between red blood cells in the circulation. Anti-glycophorin A has been used to characterize erythroid cell development and in the diagnosis of erythroid leukemias.

Glycophorins A and B are major sialoglycoproteins expressed across the surface of the human erythrocyte membrane and contain the antigenic determinants that define the MNS blood group system. The high sialic acid content of glycophorin A contributes to the generation of a net negative surface charge across erythrocyte membranes that minimizes interactions between red blood cells and prevents their aggregation. Anti-glycophorin A has utility in identifying cells of the erythroid lineage.

Qualidade

IVD

IVD

IVD

RUO

Ligação

Glycophorin A Positive Control Slides, Product No. 260S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

forma física

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Nota de preparo

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Outras notas

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informações legais

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany