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PHR1375

Supelco

Ketoprofen

Pharmaceutical Secondary Standard; Certified Reference Material

Sinônimo(s):

Ketoprofen, KP, 2-(3-Benzoylphenyl)propionic acid

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About This Item

Fórmula empírica (Notação de Hill):
C16H14O3
Número CAS:
Peso molecular:
254.28
Número CE:
Número MDL:
Código UNSPSC:
41116107
ID de substância PubChem:
NACRES:
NA.24

grau

certified reference material
pharmaceutical secondary standard

Nível de qualidade

Agency

traceable to BP 668
traceable to Ph. Eur. K2000000
traceable to USP 1356632

família API

ketoprofen

Certificado de análise (CofA)

current certificate can be downloaded

técnica(s)

HPLC: suitable
gas chromatography (GC): suitable

aplicação(ões)

pharmaceutical (small molecule)

formato

neat

temperatura de armazenamento

2-30°C

cadeia de caracteres SMILES

CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2

InChI

1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)

chave InChI

DKYWVDODHFEZIM-UHFFFAOYSA-N

Informações sobre genes

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Descrição geral

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Ketoprofen is an active pharmaceutical compound used as a non-steroidal anti-inflammatory drug (NSAID). It is essentially a non-narcotic drug extensively utilized for mild to moderate pain relief.

Aplicação

Ketoprofen may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography and spectrophotometric technique.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Ações bioquímicas/fisiológicas

Non-steroidal anti-inflammatory compound that is selective for COX-1.

Nota de análise

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Outras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota de rodapé

To see an example of a Certificate of Analysis for this material enter LRAC3470 in the slot below. This is an example certificate only and may not be the lot that you receive.

Produtos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Pictogramas

Skull and crossbonesEnvironment

Palavra indicadora

Danger

Frases de perigo

Classificações de perigo

Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Choose from one of the most recent versions:

Certificados de análise (COA)

Lot/Batch Number

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Simultaneous HPLC determination of ketoprofen and its degradation products in the presence of preservatives in pharmaceuticals
Dvorak J, et al.
Journal of Pharmaceutical and Biomedical Analysis, 36(3), 625-629 (2004)
UV-spectrophotometric determination of ketoprofen and paraben in a gel preparation by partial least-squares calibration
Blanco M, et al.
Fresenius Journal of Analytical Chemistry, 357(7), 967-972 (1997)
Development and validation of a stability-indicating high-performance liquid chromatographic assay for ketoprofen topical penetrating gel
Bempong DK and Bhattacharyya L
Journal of Chromatography A, 1073(1-2), 341-346 (2005)
Fabíola Garavello Prezotti et al.
Carbohydrate polymers, 113, 286-295 (2014-09-27)
Gellan gum/pectin beads were prepared by ionotropic gelation, using Al(3+) as crosslinker. High yield (92.76%) and entrapment efficiency (52.22-88.78%) were reached. Beads exhibited high circularity (0.730-0.849) and size between 728.95 and 924.56 μm. Particle size and circularity was increased by
F Jamali et al.
Clinical pharmacokinetics, 19(3), 197-217 (1990-09-01)
Ketoprofen, a potent nonsteroidal anti-inflammatory drug (NSAID) of the 2-arylpropionic acid class, has been used clinically for over 15 years in Europe, and has recently been introduced in the United States. Although it possesses a chiral centre, with only the

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