A7085

Acetaminofeno

BioXtra, ≥99.0%

• Sinônimo(s): 4′-Hidroxiacetanilida, 4-Acetamidofenol, N-(4-Hidroxifenil)acetamida, N-Acetil-4-aminofenol, APAP, Paracetamol
• Fórmula linear: CH₃CONHC₆H₄OH
• Número CAS: 103-90-2
• Peso molecular: 151.16
• Beilstein: 2208089
• Número CE: 203-157-5
• Número MDL: MFCD00002328
• Código UNSPSC: 12352111
• ID de substância PubChem: 24891173
• NACRES: NA.25

Propriedades

• linha de produto: BioXtra
• Nível de qualidade: 200
• Ensaio: ≥99.0%
• forma: powder
• Impurezas: ≤0.0005% Phosphorus (P); ≤0.1% Insoluble matter
• resíduo de ignição: ≤0.1%
• pf: 168-172 °C (lit.)
• solubilidade: ethanol: 0.5 M, clear, colorless
• traços de ânion: chloride (Cl^-): ≤0.05%; sulfate (SO₄^2-): ≤0.05%
• traços de cátion: Al: ≤0.0005%; Ca: ≤0.0005%; Cu: ≤0.0005%; Fe: ≤0.0005%; K: ≤0.005%; Mg: ≤0.0005%; NH₄⁺: ≤0.05%; Na: ≤0.005%; Pb: ≤0.001%; Zn: ≤0.0005%
• cadeia de caracteres SMILES: CC(=O)Nc1ccc(O)cc1
• InChI: 1S/C8H9NO2/c1-6(10)9-7-2-4-8(11)5-3-7/h2-5,11H,1H3,(H,9,10)
• chave InChI: RZVAJINKPMORJF-UHFFFAOYSA-N
• Informações sobre genes: human ... FAAH(2166) , PTGS1(5742) , PTGS2(5743) , TRPV1(7442)

Descrição

Descrição geral

Acetaminophen or paracetamol is an analgesic and antipyretic. It is however a weak non opioid analgesic.

Aplicação

Acetaminophen has been used:

• as an anti-inflammatory drug to test its effect in lipid peroxidation in marine mussels
• to test its effect on neurite outgrowth in gamma-aminobutyric acid-ergic and glutamatergic neurons
• as a hepatocellular injury inducing agent in mice

Analgésico.

Ações bioquímicas/fisiológicas

Acetaminophen or paracetamol is an inhibitor of prostaglandin synthesis. It is complexed with arachidonic acid in central nervous system resulting in the formation of N-arachidonoylphentolamine, which is essential for the activation of cannabinoid receptor. Acetaminophen is metabolized to toxic N-acetyl-p-benzoquinone imine. Paracetamol is prescribed for osteoarthritis pain and inhibits cyclooxygenase 1 and 2 activities. It is metabolized by the cytochrome P450 enzymes in liver and is implicated in liver toxicity.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H302
• Declarações de precaução: P264 - P270 - P301 + P312 - P501
• Classificações de perigo: Acute Tox. 4 Oral
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): 364.3 °F - Pensky-Martens closed cup
• Ponto de fulgor (°C): 184.6 °C - Pensky-Martens closed cup
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves