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78780

Sigma-Aldrich

Phenyl isothiocyanate

for HPLC derivatization, the detection of alcohols and amines, ≥99.0%

Sinônimo(s):

PITC

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25 ML
R$ 357,00
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R$ 1.130,00
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R$ 4.073,00

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Disponível para enviar em01 de abril de 2025Detalhes

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25 ML
R$ 357,00
100 ML
R$ 1.130,00
500 ML
R$ 4.073,00

About This Item

Fórmula linear:
C6H5NCS
Número CAS:
103-72-0
Peso molecular:
135.19
Beilstein:
471392
Número CE:
203-138-1
Número MDL:
MFCD00004798
Código UNSPSC:
12352100
ID de substância PubChem:
57652756
NACRES:
NA.21

R$ 357,00

Disponível para enviar em01 de abril de 2025Detalhes

Solicite uma grande encomenda

Nível de qualidade

200

Ensaio

≥99.0%

Formulário

liquid

qualidade

for HPLC derivatization, the detection of alcohols and amines

índice de refração

n20/D 1.649
n20/D 1.6515 (lit.)

p.e.

218 °C (lit.)

pf

−21 °C (lit.)

solubilidade

water: insoluble

densidade

1.13 g/mL at 20 °C
1.132 g/mL at 20 °C (lit.)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

S=C=Nc1ccccc1

InChI

1S/C7H5NS/c9-6-8-7-4-2-1-3-5-7/h1-5H

chave InChI

QKFJKGMPGYROCL-UHFFFAOYSA-N

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Descrição geral

Phenyl isothiocyanate is an aromatic isothiocyanate. It participates in dehydration reactions of alcohols.[1] It is widely used for synthesis of various biologically important heterocyclic compounds.[2]

Aplicação

Derivatizing reagent for primary and secondary amines. Used in sequencing peptides by Edman degradation and in amino acid analyses by HPLC.
Phenyl isothiocyanate may be employed as a derivatization reagent for high-performance liquid chromatographic (HPLC) analysis of various amphetamine derivatives in body fluids.[3]

Atenção

Store under Argon

Produtos recomendados

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Palavra indicadora

Danger

Frases de perigo

H301,H314,H317,H334

Classificações de perigo

Acute Tox. 3 Oral - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

Código de classe de armazenamento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

190.4 °F - closed cup

Ponto de fulgor (°C)

88 °C - closed cup

Equipamento de proteção individual

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
BCCM8732
BCCM7882
BCCK3507
BCCG8125
BCCD5138

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Pesquise por COA

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Amin Zolali et al.
Combinatorial chemistry & high throughput screening, 17(7), 610-613 (2014-03-19)
An efficient, one-pot and three-component synthesis of biologically important heterocyclic compounds is described from the reaction of primary amines and phenyl isothiocyanate in the presence of acryloyl chloride at room temperature without the need to use any catalyst.
One-pot dehydrations using phenyl isothiocyanate.
Majetich G, et al.
Tetrahedron Letters, 56(23), 3326-3329 (2015)
Determination of phenylisothiocyanate derivatives of amphetamine and its analogues in biological fluids by HPLC-APCI-MS or DAD.
Bogusz MJ, et al.
Journal of Analytical Toxicology, 21(1), 59-69 (1997)
Fantao Meng et al.
Bioconjugate chemistry, 19(7), 1352-1360 (2008-06-25)
Successful and cost-effective PEGylation protocols require pure functionalized PEG reagents, which can be synthesized by simple and efficient procedures, exhibit high stability against hydrolysis, and maintain a level of reactivity with protein functional groups under mild reaction conditions. PEG-phenyl-isothiocyanate (PIT-PEG)
R Thippeswamy et al.
Journal of agricultural and food chemistry, 54(19), 7014-7019 (2006-09-14)
Two liquid chromatographic methods that involve precolumn derivatization with o-phthaladehyde (OPA) and phenylisothiocyanate (PITC) with fluorescence and diode array UV detection for the determination of theanine have been developed. The chromatographic separations were achieved by reverse-phase high-performance liquid chromatography using
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Questions

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  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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