About This Item
Código UNSPSC:
12352202
eCl@ss:
32160405
NACRES:
NA.41
Produtos recomendados
fonte biológica
human
Nível de qualidade
100
300
Ensaio
>98% (SDS-PAGE)
forma
liquid
fabricante/nome comercial
Chemicon®
concentração
3.5 mg/mL
nº de adesão NCBI
nº de adesão UniProt
Descrição geral
C-reactive protein (CRP) is a homopentameric acute-phase inflammatory protein, which belongs to the pentraxin family. It is a highly conserved plasma protein produced mainly in liver hepatocytes. It is also synthesized by lymphocytes, smooth muscle cells, macrophages, endothelial cells, and adipocytes.
Aplicação
C-reactive protein (CRP) has been used:
- as a model analyte for interference-reduced detection of CRP in serum using non-competitive sandwich immunoassay in combination with surface plasmon field-enhanced fluorescence spectroscopy (SPFS)
- to determine the involvement of collectin placenta 1 (CL-P1) in CRP-mediated complement activation and to investigate the downstream effects of this complement activation
- to examine to study the effects of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) on CRP-induced complement activation by interacting with CRP to develop an inflammatory pathogenic response
Ações bioquímicas/fisiológicas
C-reactive protein (CRP) plays a vital role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release. It also regulates the production of interleukin-6 and tumor necrosis factor-α. Patients suffering from appendicitis, cholecystitis, pancreatitis, and meningitis have elevated levels of CRP. CRP facilitates the uptake of low-density lipoprotein in macrophages. It has a crucial role in the pathophysiology of cardiovascular disease, which makes it a useful marker for inflammation and cardiovascular events.
Qualidade
No precipitin bands when tested at 2 mg/mL against anti-whole human serum.
forma física
Liquid in 100mM NaCl, 10mM Tris-HCl with 0.1% sodium azide, 2mM CaCl2
Armazenamento e estabilidade
Maintain under sterile conditions at 2-8°C for up to one year. Do not freeze. Full safety precautions should be taken as in the handling of any potentially infective body fluid.
Informações legais
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
nwg
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Certificados de análise (COA)
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Nitai Roy et al.
Biochimica et biophysica acta, 1860(6), 1118-1128 (2016-03-01)
C-reactive protein (CRP) is a plasma pentraxin family protein that is massively induced as part of the innate immune response to infection and tissue injury. CRP and other pentraxin proteins can activate a complement pathway through C1q, collectins, or on
Development of a cluster of differentiation antibody-based protein microarray.
Michael Abdo, Bob Irving, Peter Hudson, Heddy Zola
Journal of Immunological Methods null
Yoshiko Fujita et al.
Clinical chemistry, 56(3), 478-481 (2010-01-16)
C-reactive protein (CRP) increases in response to inflammation and is purported to be a risk factor for atherogenesis. We recently demonstrated that a scavenger receptor, lectin-like oxidized LDL receptor (LOX-1), is a receptor for CRP. In light of the overlapping
Lectin-like Oxidized LDL Receptor 1 Is Involved in CRP-Mediated Complement Activation.
Fujita Y, Yamaguchi S, Kakino A, Iwamoto S, Yoshimoto R, Sawamura T.
Clinical Chemistry null
Charles R Kiefer et al.
Clinica chimica acta; international journal of clinical chemistry, 413(19-20), 1536-1541 (2012-06-28)
We evaluated the utility of an independent biomarker of early ischemic cellular damage-circulating fractional forms of C-reactive protein (fracCRP), to verify the diagnostic relevance of low Troponin I (TnI) values within the context of a workup for Acute Coronary Syndrome
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