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SRP6267

Sigma-Aldrich

C-reactive/CRP human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sinônimo(s):

C-reactive protein, CRP, PTX1

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

fonte biológica

human

recombinante

expressed in HEK 293 cells

etiqueta

6-His tagged (C-terminus)

Ensaio

≥95% (SDS-PAGE)

forma

lyophilized powder

peso molecular

calculated mol wt 24 kDa
observed mol wt 26 kDa (DTT-reduced. Phe17 is the predicted N-terminus.)

embalagem

pkg of 100 μg

Impurezas

<1 EU/μg endotoxin (LAL test)

nº de adesão UniProt

P02741

Condições de expedição

wet ice

temperatura de armazenamento

−20°C

Informações sobre genes

human ... CRP(1401)

Descrição geral

C-reactive protein (CRP) is a member of the pentraxin family of proteins that are characterized by a cyclic pentameric structure. Human CRP gene encodes a 224 amino acids precursor. The mature human CRP protein has 206 amino acids that are noncovalently linked to form the pentameter. Human CRP shares 71% and 64% amino acid sequence homology with mouse and rat, respectively.

Ações bioquímicas/fisiológicas

CRP, synthesized by hepatocytes, is a major acute phase serum protein in human. IL6, IL1 and glucocorticoids are the major inducer of the CRP gene. The physiological role of CRP is to bind to phosphocholine expressed on the surface of dead or dying cells (and some types of bacteria) in order to activate the complement system. CRP binds to phosphocholine on microbes and damaged cells and enhances phagocytosis by macrophages. Thus, CRP participates in the clearance of necrotic and apoptotic cells. It has been shown that high levels of CRP in humans is associated with an increased risk of cardiovascular diseases.

forma física

Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

Reconstituição

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Visite a Biblioteca de Documentos

C-reactive protein attenuates endothelial progenitor cell survival, differentiation, and function: further evidence of a mechanistic link between C-reactive protein and cardiovascular disease.
Verma S
Circulation, 109, 2058-2067 (2004)
Yeongseok Jang et al.
Nanoscale, 12(18), 9980-9990 (2020-03-05)
We present multiple-bent multi-walled carbon nanotubes (MWCNTs) that enable the picomolar detection of C-reactive protein (CRP), which is considered to be a promising biomarker for various diseases. The MWCNTs were grown via chemical vapor deposition repeating the asymmetric catalytic CNT
Function of C-reactive protein
Du Clos TW
Annals of Medicine, 32, 274-278 (2000)
Human C-reactive protein: expression, structure, and function.
Volanakis JE
Molecular Immunology, 38, 189-197 (2001)

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