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475989

Sigma-Aldrich

MTT

Membrane-permeable yellow dye that is reduced by mitochondrial reductases in living cells to form the dark blue product, MTT-formazan.

Sinônimo(s):

MTT, 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium Bromide, Thiazole Blue

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About This Item

Fórmula empírica (Notação de Hill):
C18H16BrN5S
Número CAS:
298-93-1
Peso molecular:
414.32
Número MDL:
MFCD00011964
Código UNSPSC:
12171500
NACRES:
NA.25
Preço e disponibilidade não estão disponíveis no momento.

Nível de qualidade

100

descrição

RTECS - XF8060000

Ensaio

≥98% (silver nitrate titration)

Formulário

solid

fabricante/nome comercial

Calbiochem®

condição de armazenamento

OK to freeze

Impurezas

≤0.5% Sulfated ash

cor

yellow

solubilidade

PBS: 2 mg/mL

traços de cátion

heavy metals: ≤0.001%

Condições de expedição

ambient

temperatura de armazenamento

15-25°C

cadeia de caracteres SMILES

[s]1c(nc(c1C)C)[n]2[n+](nc(n2)c4ccccc4)c3ccccc3.[Br-]

InChI

1S/C18H16N5S.BrH/c1-13-14(2)24-18(19-13)23-21-17(15-9-5-3-6-10-15)20-22(23)16-11-7-4-8-12-16;/h3-12H,1-2H3;1H/q+1;/p-1

chave InChI

AZKSAVLVSZKNRD-UHFFFAOYSA-M

Categorias relacionadas

Descrição geral

Membrane-permeable yellow dye that is reduced by mitochondrial reductases in living cells to form the dark blue product, MTT-formazan. Spectrophotometric measurement of MTT-formazan at 540 or 570 nm allows quantitation of cell viability. Used as a direct indicator of cytotoxicity (such as for screening cancer drugs) and apoptosis. An electron acceptor used for studying NADP-dependent dehydrogenases.

Ações bioquímicas/fisiológicas

Cell permeable: yes
Primary Target
Used as a direct indicator of cytotoxicity and apoptosis.
Product does not compete with ATP.
Reversible: no

Advertência

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C.). Stock solutions are stable for up to 1 month at -20°C.

Outras notas

Liu, Y., et al. 1997. J. Neurochem.69, 581.
Abdallah, M.A. 1980. Eur. J. Biochem. 112, 331.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335,H341

Classificações de perigo

Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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