427218

FX11

≥96% (HPLC), solid, lactate dehydrogenase A inhibitor, Calbiochem^®

• Sinônimo(s): Lactate Dehydrogenase A Inhibitor, FX11
• Fórmula empírica (Notação de Hill): C₂₂H₂₂O₄
• Número CAS: 213971-34-7
• Peso molecular: 350.41
• Número MDL: MFCD00080561
• Código UNSPSC: 12352200
• NACRES: NA.54

Propriedades

• Nome do produto: Lactate Dehydrogenase A Inhibitor, FX11, Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).
• Nível de qualidade: 100
• Ensaio: ≥96% (HPLC)
• Formulário: solid
• potência: 8 μM K_i
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: DMSO: 50 mg/mL
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C

Descrição

Descrição geral

A cell permeable, gossypol analog that acts as a selective, reversible, and NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; K_i = 8 µM for human liver LDHA). Does not affect the activities of LDHB and glyceraldehyde-3-phosphate dehydrogenase even at higher concentrations. Shown to increase oxygen consumption, reactive oxygen species production, and cell death in P493 human lymphoma B cells. Also shown to reduce mitochondrial transmembrane potential and ATP levels and increase AMP kinase activity. Exhibits synergistic toxicity in P493 cells when combined with FK866 (Cat. No. 481908). Blocks the progression of human lymphoma and pancreatic cancer xenografts and when used in combination with FK866 it induces lymphoma regression.

Aplicação

Lactate Dehydrogenase A Inhibitor, FX11, CAS 213971-34-7, is a cell permeable, selective, reversible, NADH competitive inhibitor of lactate dehhydrogenase A (LDHA; Ki = 8 µM for human liver LDHA).

Ações bioquímicas/fisiológicas

Cell permeable: yes

Primary Target
LDHA

Advertência

Toxicity: Standard Handling (A)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Outras notas

Le, A., et al. 2011. Proc Natl Acad Sci USA.107, 2037.
Deck, L. M., et al. 1998. J Med Chem.41, 3879.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable