116860

Adenosine Deaminase Inhibitor, DCF

The Adenosine Deaminase Inhibitor, DCF, also referenced under CAS 53910-25-1, controls the biological activity of Adenosine Deaminase.

• Sinônimo(s): Adenosine Deaminase Inhibitor, DCF, 2ʹ-Deoxycoformycin, (8R)-3-(2-deoxy-β-D-erythro- pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, Pentostatin, S. antibioticus
• Fórmula empírica (Notação de Hill): C₁₁H₁₆N₄O₄
• Número CAS: 53910-25-1
• Peso molecular: 268.27
• Código UNSPSC: 12352200
• NACRES: NA.54

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• forma: solid
• fabricante/nome comercial: Calbiochem^®
• condição de armazenamento: OK to freeze; protect from light
• cor: white
• solubilidade: DMSO: 10 mg/mL, clear, colorless; water: 50 mg/mL, clear, colorless
• Condições de expedição: ambient
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O[C@@H]1CNC=NC2=C1N=CN2[C@@H]3O[C@H](CO)[C@H](O)C3[H]
• InChI: 1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
• chave InChI: FPVKHBSQESCIEP-JQCXWYLXSA-N

Descrição

Descrição geral

A cell-permeable purine nucleoside compound that acts as a highly potent, tight binding transition state analog inhibitor of adenosine deaminase (ADA; K_i= 2.5 pM against partially purified human erythrocytes, and 0.48 to 9.1 nM against rat liver, rat intestine, rat hepatoma and human B cells). Reported to be an immunomodulator and exert selective toxicity towards lymphocytes.

Embalagem

Packaged under inert gas

Advertência

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstituição

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Outras notas

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Robak, T. 2007. Cancer Treat. Rev.33, 710.
Klohs, W.D. and Kraker, A.J., 1992. Pharmacol. Rev.44, 459.
Agarwal, R.P., et al. 1977. Biochem. Pharmacol.26, 359.

Informações legais

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H301
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 3 Oral
• Código de classe de armazenamento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable