D9766

Dipyridamole

≥98% (HPLC), powder, phosphodiesterase V inhibitor

• Sinônimo(s): NSC 515776, NSC 619103
• Fórmula empírica (Notação de Hill): C₂₄H₄₀N₈O₄
• Número CAS: 58-32-2
• Peso molecular: 504.63
• Número CE: 200-374-7
• Número MDL: MFCD00010555
• Código UNSPSC: 41106305
• ID de substância PubChem: 24277705
• NACRES: NA.77

Propriedades

• Nome do produto: Dipyridamole, ≥98% (HPLC)
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: yellow
• pf: 165-166 °C (lit.)
• solubilidade: DMSO: soluble; ethanol: soluble
• originador: Boehringer Ingelheim
• temperatura de armazenamento: room temp
• cadeia de caracteres SMILES: OCCN(CCO)c1nc(N2CCCCC2)c3nc(nc(N4CCCCC4)c3n1)N(CCO)CCO
• InChI: 1S/C24H40N8O4/c33-15-11-31(12-16-34)23-26-20-19(21(27-23)29-7-3-1-4-8-29)25-24(32(13-17-35)14-18-36)28-22(20)30-9-5-2-6-10-30/h33-36H,1-18H2
• chave InChI: IZEKFCXSFNUWAM-UHFFFAOYSA-N
• Informações sobre genes: human ... CYP1A2(1544) , PDE10A(10846) , PDE1A(5136) , PDE1B(5153) , PDE1C(5137) , PDE2A(5138) , PDE3A(5139) , PDE3B(5140) , PDE4A(5141) , PDE4B(5142) , PDE4C(5143) , PDE4D(5144) , PDE5A(8654) , PDE6A(5145) , PDE6B(5158) , PDE6C(5146) , PDE6D(5147) , PDE6G(5148) , PDE6H(5149) , PDE7A(5150) , PDE7B(27115) , PDE8A(5151) , PDE8B(8622) , PDE9A(5152) , SLC29A1(2030) ; mouse ... Slc29a1(63959)

Descrição

Descrição geral

Dipyridamole prevents cellular uptake of adenosine.[1] It functions as an equilibrative nucleoside transporter 1 (ENT1) inhibitor.[2]

Aplicação

Dipyridamole has been used:

• to perform in vitro growth inhibition assay(40)
• to determine its ability to prevent uterine myometrial contractions(41)
• to determine its effects on nicotinamide adenine dinucleotide (NAD+)-induced increase in intracellular adenosine triphosphate (ATP) levels(42)
• to prevent nicotinamide riboside (NR)-induced axonal protection(43)

Ações bioquímicas/fisiológicas

Selective inhibitor of phosphodiesterase V (PDE 5); potent coronary vasodilator drug; adenosine transport inhibitor; inhibitor of platelet aggregation.

Características e benefícios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Phosphodiesterases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: dust mask type N95 (US), Eyeshields, Gloves