G6752

Guanosine

≥98%

• Sinônimo(s): 9-(β-D-Ribofuranosyl)guanine, Guanine-9-β-D-ribofuranoside
• Fórmula empírica (Notação de Hill): C₁₀H₁₃N₅O₅
• Número CAS: 118-00-3
• Peso molecular: 283.24
• Beilstein: 625911
• Número CE: 204-227-8
• Número MDL: MFCD00010182
• Código UNSPSC: 41106305
• ID de substância PubChem: 24895268
• NACRES: NA.51

Propriedades

• fonte biológica: microbial
• Nível de qualidade: 100; 200
• Ensaio: ≥98%
• Formulário: powder
• pf: 250 °C (dec.) (lit.)
• solubilidade: formic acid:water (1:1): 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
• cadeia de caracteres SMILES: [H]O[H].NC1=Nc2c(ncn2[C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6-,9-/m1/s1
• chave InChI: NYHBQMYGNKIUIF-UUOKFMHZSA-N

Descrição

Descrição geral

Guanosine is an aromatic organic molecule and a purine nucleoside.[1] It is present in the cerebrospinal fluid, intestinal cells, blood-brain barrier and in brain microvessels.[2]

Aplicação

Guanosine has been used:

• as a reference standard for the analysis of glucosinolates by high-performance liquid chromatography with diode-array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS)[3]
• as a component of Mouse Embryonic Fibroblasts (MEFs) culture[4]
• as a standard for the detection of residual RNA contaminant in oil palm plant genome samples by HPLC[5]

Ações bioquímicas/fisiológicas

Guanosine nucleoside elicits cellular effect as the guanine-based purinergic system. It modulates glutamate uptake by glutamate transporters. It may have neuroprotective functionality in central nervous system disorders.[1] Guanosine promotes neurite arborization, outgrowth, proliferation and differentiation.[2] Administration of guanosine replenished GTP and elicits protective function in renal ischemic injury.[6]

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges